Discovery of succinate dehydrogenase candidate fungicides via lead optimization for effective resistance management of Fusarium oxysporum f. sp. capsici

Fusarium wilt of chili caused by the fungus Fusarium oxysporum f. sp. capsici (FCO) severely reduces the production of chili worldwide. There is growing evidence of resistance to commercial fungicides targeting succinate dehydrogenase (Sdh) of FCO soliciting the development of new Sdh inhibitors (Sd...

Full description

Saved in:
Bibliographic Details
Published in:3 Biotech 2022-04, Vol.12 (4), p.102-102, Article 102
Main Authors: Iftikhar, Sehrish, Bengyella, Louis, Shahid, Ahmad Ali, Nawaz, Kiran, Anwar, Waheed, Khan, Azhar Ali
Format: Article
Language:English
Subjects:
Agriculture
Bioinformatics
Biomaterials
Biotechnology
Cancer Research
Chemistry
Chemistry and Materials Science
Dehydrogenases
Fungicidal activity
Fungicides
Fusarium oxysporum
Germination
Optimization
Original
Original Article
Pesticides
Spore germination
Stem Cells
Succinate dehydrogenase
Wilt
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Fusarium wilt of chili caused by the fungus Fusarium oxysporum f. sp. capsici (FCO) severely reduces the production of chili worldwide. There is growing evidence of resistance to commercial fungicides targeting succinate dehydrogenase (Sdh) of FCO soliciting the development of new Sdh inhibitors (SdhIs). In the current work, optimized docking and virtual screening were used to mine twelve SdhIs from the ZINC database, followed by in vitro antifungal evaluation on spore and radial mycelium development. Four new promising SdhIs exhibiting a mean mycelium inhibition rate greater than 85.6% ( F =  155.8, P =  0.001, P  
ISSN:2190-572X
2190-5738
DOI:10.1007/s13205-022-03157-8