Influence of a pulmonary surfactant on the in vitro activity of tobramycin against Pseudomonas aeruginosa

Delivery of therapeutic concentrations of drugs to the lung periphery is crucial in treatment of many infectious and inflammatory diseases of the lung. Intratracheal instillation of surfactant, in the animal model, increased the fractional area of lung exposed and improved the uniformity of spread o...

Full description

Saved in:
Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 1999-12, Vol.43 (12), p.3044-3044
Main Authors: Caldwell, E J, Piper, D S
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents
Anti-Bacterial Agents - pharmacology
Commented On
Letters to the Editor
Microbial Sensitivity Tests
Pseudomonas aeruginosa
Pseudomonas aeruginosa - drug effects
Pulmonary Surfactants
Pulmonary Surfactants - pharmacology
Tobramycin
Tobramycin - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Delivery of therapeutic concentrations of drugs to the lung periphery is crucial in treatment of many infectious and inflammatory diseases of the lung. Intratracheal instillation of surfactant, in the animal model, increased the fractional area of lung exposed and improved the uniformity of spread of radioactive label in the lung compared to the saline control. We examined the effect of physical perturbation with the mixture, antibiotic, and surfactant, via heat and sonication and stability over time as a function of the MIC for Pseudomonas. When tobramycin and surfactant were mixed, sonicated, and heated to 80 degree C for 30 min, there was no in vitro reduction in MIC for P. aeruginosa.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.43.12.3044