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Influence of a pulmonary surfactant on the in vitro activity of tobramycin against Pseudomonas aeruginosa

Delivery of therapeutic concentrations of drugs to the lung periphery is crucial in treatment of many infectious and inflammatory diseases of the lung. Intratracheal instillation of surfactant, in the animal model, increased the fractional area of lung exposed and improved the uniformity of spread o...

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Published in:	Antimicrobial agents and chemotherapy 1999-12, Vol.43 (12), p.3044-3044
Main Authors:	Caldwell, E J, Piper, D S
Format:	Article
Language:	English
Subjects:	Anti-Bacterial Agents Anti-Bacterial Agents - pharmacology Commented On Letters to the Editor Microbial Sensitivity Tests Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Pulmonary Surfactants Pulmonary Surfactants - pharmacology Tobramycin Tobramycin - pharmacology
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description	Delivery of therapeutic concentrations of drugs to the lung periphery is crucial in treatment of many infectious and inflammatory diseases of the lung. Intratracheal instillation of surfactant, in the animal model, increased the fractional area of lung exposed and improved the uniformity of spread of radioactive label in the lung compared to the saline control. We examined the effect of physical perturbation with the mixture, antibiotic, and surfactant, via heat and sonication and stability over time as a function of the MIC for Pseudomonas. When tobramycin and surfactant were mixed, sonicated, and heated to 80 degree C for 30 min, there was no in vitro reduction in MIC for P. aeruginosa.
doi_str_mv	10.1128/AAC.43.12.3044
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source	Open Access: PubMed Central; American Society for Microbiology Journals
subjects	Anti-Bacterial Agents Anti-Bacterial Agents - pharmacology Commented On Letters to the Editor Microbial Sensitivity Tests Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Pulmonary Surfactants Pulmonary Surfactants - pharmacology Tobramycin Tobramycin - pharmacology
title	Influence of a pulmonary surfactant on the in vitro activity of tobramycin against Pseudomonas aeruginosa
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