Study of the Nanofibers Fabrication Conditions from the Mixture of Poly(vinyl alcohol) and Chitosan by Electrospinning Method

Nanofiber fabrication is attracting great attention from scientists and technologists due to its applications in many fields of life. In order to design a nanosized polymer-based drug delivery system, we studied the conditions for the fabrication of electrospun nanofibers from poly (vinyl alcohol) (...

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Bibliographic Details
Published in:Polymers 2022-02, Vol.14 (4), p.811
Main Authors: Vu, Thi Hong Nhung, Morozkina, Svetlana N, Uspenskaya, Mayya V
Format: Article
Language:English
Subjects:
Acetic acid
Bioavailability
Biocompatibility
Biodegradability
Biodegradable materials
Chitosan
Drug delivery systems
Electrospinning
Enzymes
Feed rate
Hydrogels
Mechanical properties
Nanofibers
Polymers
Polyvinyl alcohol
Tissue engineering
Wound healing
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Summary:Nanofiber fabrication is attracting great attention from scientists and technologists due to its applications in many fields of life. In order to design a nanosized polymer-based drug delivery system, we studied the conditions for the fabrication of electrospun nanofibers from poly (vinyl alcohol) (PVA) and chitosan (CS), which are well-known as biocompatible, biodegradable and non-toxic polymers that are widely used in the medical field. Aiming to develop nanofibers that can directly target diseased cells for treatment, such as cancerous cells, the ideal choice would be a system that contains the highest CS content as well as high quality fibers. In the present manuscript, it is expected to become the basis for improving the low bioavailability of medicinal drugs limited by poor solubility and low permeability. PVA-CS nanofibers were obtained by electrospinning at a PVA:CS ratio of 5:5 in a 60% ( / ) acetic acid solution under the following parameters: voltage 30 kV, feed rate 0.2 mL/h, needle-collector distance 14 cm. The obtained fibers were relatively uniform, with a diameter range of 77-292 nm and average diameter of 153 nm. The nanofiber system holds promise as a potential material for the integration of therapeutic drugs.
ISSN:2073-4360
2073-4360
DOI:10.3390/polym14040811