Diagnostic performance of endoscopic classifications for neoplastic lesions in patients with ulcerative colitis: A retrospective case-control study

• Published in: World journal of gastroenterology : WJG 2022-03, Vol.28 (10), p.1055-1066
• Main Authors: Kida, Yuichi, Yamamura, Takeshi, Maeda, Keiko, Sawada, Tsunaki, Ishikawa, Eri, Mizutani, Yasuyuki, Kakushima, Naomi, Furukawa, Kazuhiro, Ishikawa, Takuya, Ohno, Eizaburo, Kawashima, Hiroki, Nakamura, Masanao, Ishigami, Masatoshi, Fujishiro, Mitsuhiro
• Format: Article
• Language: English
• Subjects: Carcinoma - complications; Case-Control Studies; Colitis, Ulcerative - complications; Colonoscopy - methods; Colorectal Neoplasms - pathology; Humans; Hyperplasia; Narrow Band Imaging - methods; Retrospective Studies; Retrospective Study
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v28.i10.1055

It is unclear whether the Japan Narrow-Band Imaging Expert Team (JNET) classification and pit pattern classification are applicable for diagnosing neoplastic lesions in patients with ulcerative colitis (UC). To clarify the diagnostic performance of these classifications for neoplastic lesions in patients with UC. This study was conducted as a single-center, retrospective case-control study. Twenty-one lesions in 19 patients with UC-associated neoplasms (UCAN) and 23 lesions in 22 UC patients with sporadic neoplasms (SN), evaluated by magnifying image-enhanced endoscopy, were retrospectively and separately assessed by six endoscopists (three experts, three non-experts), using the JNET and pit pattern classifications. The results were compared with the pathological diagnoses to evaluate the diagnostic performance. Inter- and intra-observer agreements were calculated. In this study, JNET type 2A and pit pattern type III/IV were used as indicators of low-grade dysplasia, JNET type 2B and pit pattern type V low irregularity were used as indicators of high-grade dysplasia to shallow submucosal invasive carcinoma, JNET type 3 and pit pattern type V high irregularity/V were used as indicators of deep submucosal invasive carcinoma. In the UCAN group, JNET type 2A and pit pattern type III/IV had a low positive predictive value (PPV; 50.0% and 40.0%, respectively); however, they had a high negative predictive value (NPV; 94.7% and 100%, respectively). Conversely, in the SN group, JNET type 2A and pit pattern type III/IV had a high PPV (100% for both) but a low NPV (63.6% and 77.8%, respectively). In both groups, JNET type 3 and pit pattern type V -high irregularity/V showed high specificity. The inter-observer agreement of JNET classification and pit pattern classification for UCAN among experts were 0.401 and 0.364, in the same manner for SN, 0.666 and 0.597, respectively. The intra-observer agreements of JNET classification and pit pattern classification for UCAN among experts were 0.387, 0.454, for SN, 0.803 and 0.567, respectively. The accuracy of endoscopic diagnosis using both classifications was lower for UCAN than for SN. Endoscopic diagnosis of UCAN tended to be underestimated compared with the pathological results.