Obstructive Sleep Apnea as a Risk Factor for Venous Thromboembolism: A Systematic Review

Obstructive sleep apnea (OSA), is a prevalent condition characterized by repeated episodes of pharyngeal airway obstruction resulting in hypopnea and apnea episodes during sleep leading to nightly awakenings. OSA is a major contributor to the healthcare burden worldwide due to its high cardiovascula...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2022-02, Vol.14 (2), p.e22729-e22729
Main Authors: Raj, Rhea, Paturi, Akil, Ahmed, Mohamed A, Thomas, Sneha E, Gorantla, Vasavi Rakesh
Format: Article
Language:English
Subjects:
Airway management
Anatomy
Blood platelets
Cardiovascular disease
Cytokines
Endothelium
Glycoproteins
Hypoxia
Inflammation
Internal Medicine
Nitric oxide
Obesity
Pathology
Pathophysiology
Pulmonary embolisms
Risk factors
Shear stress
Sleep apnea
Thromboembolism
Thrombosis
Tumor necrosis factor-TNF
Viscosity
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Summary:Obstructive sleep apnea (OSA), is a prevalent condition characterized by repeated episodes of pharyngeal airway obstruction resulting in hypopnea and apnea episodes during sleep leading to nightly awakenings. OSA is a major contributor to the healthcare burden worldwide due to its high cardiovascular morbidity and mortality. There is growing evidence to support a pathophysiological link between OSA and venous thromboembolism (VTE). The pro-inflammatory state along with intermittent hypoxia that is invoked in OSA is associated with blood hypercoagulability, venous stasis, and endothelial dysfunction leading to deep vein thrombosis (DVT) and pulmonary embolism (PE). In this systematic review, we aim to analyze and assess the available literature on OSA and VTE (or DVT/PE) to determine whether OSA is an independent risk factor for VTE.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.22729