Identification of miR-4510 as a metastasis suppressor of gastric cancer through regulation of tumor microenvironment via targeting GPC3

The genes miR-4510 and glypican-3 (GPC3) have reported to be closely associated with tumors, with miR-4510 inversely correlated with GPC3 mRNA and protein in hepatocellular carcinoma samples. Glypican-3-expressing gastric cancer (GPC3-GC), characterized as gastric cancer (GC) expressing GPC3, accoun...

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Bibliographic Details
Published in:Clinical & experimental metastasis 2022-04, Vol.39 (2), p.363-374
Main Authors: Ma, Hai-fen, Shu, Peng, Shi, Xiao-hai, Wang, Min, Jiang, Mao-fen
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Cancer
Cancer Research
CD8 antigen
Cell Line, Tumor
Cell proliferation
Gastric cancer
Gene Expression Regulation, Neoplastic
Glypicans - genetics
Glypicans - metabolism
Hematology
Heparan sulfate proteoglycans
Hepatocellular carcinoma
Humans
Liver Neoplasms - genetics
Liver Neoplasms - metabolism
Lymphocytes
Lymphocytes T
Macrophages
Metastases
Metastasis
MicroRNAs - genetics
MicroRNAs - metabolism
miRNA
mRNA
Oncology
Oxaliplatin
Research Paper
Stomach Neoplasms - genetics
Stomach Neoplasms - pathology
Surgical Oncology
Tumor microenvironment
Tumor Microenvironment - genetics
Tumors
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Summary:The genes miR-4510 and glypican-3 (GPC3) have reported to be closely associated with tumors, with miR-4510 inversely correlated with GPC3 mRNA and protein in hepatocellular carcinoma samples. Glypican-3-expressing gastric cancer (GPC3-GC), characterized as gastric cancer (GC) expressing GPC3, accounts for 11% of the GC cases. However, the expression and mechanism of action of miR-4510 in GPC3-GC have not been clearly defined. We found that miR-4510 expression in GC tissues was significantly lower than that in the adjacent tissues (p 
ISSN:0262-0898
1573-7276
DOI:10.1007/s10585-021-10143-6