NDF is a transcription factor that stimulates elongation by RNA polymerase II

RNA polymerase II (Pol II) elongation is a critical step in gene expression. Here we found that NDF, which was identified as a bilaterian nucleosome-destabilizing factor, is also a Pol II transcription factor that stimulates elongation with plain DNA templates in the absence of nucleosomes. NDF bind...

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Bibliographic Details
Published in:Genes & development 2022-03, Vol.36 (5-6), p.294-299
Main Authors: Fei, Jia, Xu, Jun, Li, Ziwei, Xu, Kevin, Wang, Dong, Kassavetis, George A, Kadonaga, James T
Format: Article
Language:English
Subjects:
Humans
Nucleosomes - metabolism
Research Communication
RNA Polymerase II - metabolism
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - metabolism
Transcription Factors - genetics
Transcription Factors - metabolism
Transcription, Genetic
Transcriptional Elongation Factors - genetics
Transcriptional Elongation Factors - metabolism
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Summary:RNA polymerase II (Pol II) elongation is a critical step in gene expression. Here we found that NDF, which was identified as a bilaterian nucleosome-destabilizing factor, is also a Pol II transcription factor that stimulates elongation with plain DNA templates in the absence of nucleosomes. NDF binds directly to Pol II and enhances elongation by a different mechanism than that used by transcription factor TFIIS. Moreover, yeast Pdp3, which is related to NDF, binds to Pol II and stimulates elongation. Thus, NDF is a Pol II binding transcription elongation factor that is localized over gene bodies and is conserved from yeast to humans.
ISSN:0890-9369
1549-5477
DOI:10.1101/gad.349150.121