Recommendations for Hepatitis B Immunoglobulin and Antiviral Prophylaxis Against Hepatitis B Recurrence After Liver Transplantation

The combination of hepatitis B immunoglobulin and potent nucleos(t)ide analogs after liver transplantation is considered as the standard of care for prophylaxis against hepatitis B virus recurrence. However, the recommended doses, route of administration, and duration of HBIG administration remain u...

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Bibliographic Details
Published in:The Turkish journal of gastroenterology 2021-09, Vol.32 (9), p.712-719
Main Authors: Akarsu, Mesut, Onem, Soner, Turan, Ilker, Adali, Gupse, Akdogan, Meral, Akyildiz, Murat, Aladag, Murat, Balaban, Yasemin, Danis, Nilay, Dayangac, Murat, Gencdal, Genco, Gokcan, Hale, Sertesen, Elif, Gurakar, Merve, Harputluoglu, Murat, Kabacam, Gokhan, Karademir, Sedat, Kiyici, Murat, Idilman, Ramazan, Karasu, Zeki
Format: Article
Language:English
Subjects:
Antiviral agents
Diseases
Dosage and administration
Hepatitis B
Immunoglobulins
Liver
Prevention
Relapse
Review
Risk factors
Transplantation
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Summary:The combination of hepatitis B immunoglobulin and potent nucleos(t)ide analogs after liver transplantation is considered as the standard of care for prophylaxis against hepatitis B virus recurrence. However, the recommended doses, route of administration, and duration of HBIG administration remain unclear. Moreover, hepatitis B immunoglobulin-free prophylaxis with potent nucleos(t)ide analogs has shown promising disease outcomes in preventing hepatitis B virus recurrence. The current recommendations, produced by the Turkish Association for the Study of the Liver, Acute Liver Failure and Liver Transplantation Special Interest Group, suggest a reduced need for hepatitis B immunoglobulin administration with effective long-term suppression of hepatitis B virus replication using potent nucleos(t) ide analogs after liver transplantation. Keywords: Hepatitis B, liver transplantation, recurrence
ISSN:1300-4948
2148-5607
DOI:10.5152/tjg.2021.21608