Intrahepatic Expression of C-C Motif ligand 5 in Patients with Chronic Hepatitis B

Background: C-C motif ligand 5 (CCL5) is reported to play a key role in acute and chronic liver diseases. However, the association between CCL5 and chronic hepatitis B (CHB) remains to be explored. We aimed to investigate the CCL5 expression in the liver tissues of CHB patients and compared the CCL5...

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Published in:The Turkish journal of gastroenterology 2021-01, Vol.32 (1), p.76-81
Main Authors: Zhao, Xiang-An, Wang, Jian, Chang, Haiyan, Liu, Yong, Chen, Yuxin, Chen, Guangmei, Huang, Rui, Wu, Chao
Format: Article
Language:English
Subjects:
Chemokines
Development and progression
Gene expression
Genetic aspects
Health aspects
Hepatitis B
LIVER
Liver diseases
Original
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Summary:Background: C-C motif ligand 5 (CCL5) is reported to play a key role in acute and chronic liver diseases. However, the association between CCL5 and chronic hepatitis B (CHB) remains to be explored. We aimed to investigate the CCL5 expression in the liver tissues of CHB patients and compared the CCL5 expression among CHB patients with different stages of liver inflammation and fibrosis. Methods: Liver tissue specimens from 51 CHB patients who underwent liver biopsy and twelve healthy liver donors were included in the present study. CCL5 expression in the liver tissues was analyzed using immunohistochemistry. The hepatic inflammation grades and fibrotic stages of CHB patients were assessed by the Scheuer classification system. Results: Livers of CHB patients exhibited significantly accumulated CCL5+ cells when compared to those of healthy controls (42.80 [+ or -] 4.37 vs. 7.25 [+ or -] 0.99/HPF, P < .001). CHB patients with higher hepatic inflammation grades had more CCL5+ cells in their livers than those with lower grades (P < .05). However, the numbers of CCL5+ cells were not correlated with the fibrotic stages in CHB patients (r = .073, P = .61). The number of CCL5+ cells in the liver tissues of CHB patients was positively correlated with alanine transaminase levels (r = .278, P = .041) and aspartate aminotransferase levels (r = .328, P = .009). Conclusions: CHB patients have a significant accumulation of CCL5+ cells in the liver, and CCL5 may play a pathological role in hepatic inflammation of CHB. Keywords: CCL5, CHB, hepatic fibrosis, hepatic inflammation
ISSN:2148-5607
1300-4948
2148-5607
DOI:10.5152/tjg.2020.19566