Injectable Acylhydrazone‐Linked RAFT Polymer Hydrogels for Sustained Protein Release and Cell Encapsulation

A new class of temperature responsive polymer, termed PADO, is synthesized by reversible addition‐fragmentation chain‐transfer polymerization. Synthesized from copolymerization of diacetone acrylamide (DAAM), di(ethylene glycol) ethyl ether acrylate, and oligo(ethylene glycol) methyl ether acrylate,...

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Bibliographic Details
Published in:Advanced healthcare materials 2022-04, Vol.11 (7), p.e2101284-n/a
Main Authors: Lin, Fang‐Yi, Dimmitt, Nathan H., Moraes de Lima Perini, Mariana, Li, Jiliang, Lin, Chien‐Chi
Format: Article
Language:English
Subjects:
Acrylamide
acylhydrazone
Addition polymerization
Adipic acid
Cell Encapsulation
Copolymerization
Ethylene
Ethylene glycol
Ethylene Glycols
Hydrogels
Hydrogels - chemistry
Hydrophobicity
injectable hydrogel
Ketones
pH effects
Polymers
protein delivery
Proteins
Sol-gel processes
stimuli responses
Temperature
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Summary:A new class of temperature responsive polymer, termed PADO, is synthesized by reversible addition‐fragmentation chain‐transfer polymerization. Synthesized from copolymerization of diacetone acrylamide (DAAM), di(ethylene glycol) ethyl ether acrylate, and oligo(ethylene glycol) methyl ether acrylate, PADO polymer phase separates at temperature above its lower critical solution temperature (36–42 °C) due to enhanced hydrophobic interactions between the short ethylene glycol side chains. Solution of PADO polymers exhibit injectable shear‐thinning properties and reach sol–gel transition rapidly (
ISSN:2192-2640
2192-2659
2192-2659
DOI:10.1002/adhm.202101284