Magnetic resonance fingerprinting in prostate cancer before and after contrast enhancement

• Published in: British journal of radiology 2022-03, Vol.95 (1131), p.20210479-20210479
• Main Authors: Lee, Young Sub, Choi, Moon Hyung, Lee, Young Joon, Han, Dongyeob, Kim, Dong-Hyun
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Contrast Media - administration & dosage; Humans; Image-Guided Biopsy; Imaging, Three-Dimensional; Innovations in prostate cancer special feature : Full Paper; Male; Middle Aged; Multiparametric Magnetic Resonance Imaging - methods; Prostate-Specific Antigen - blood; Prostatic Neoplasms - diagnostic imaging; Prostatic Neoplasms - pathology; Ultrasonography, Interventional
• ISSN: 0007-1285; 1748-880X
• DOI: 10.1259/bjr.20210479

To assess the apparent diffusion coefficient (ADC) values and the T1 and T2 values derived from nonenhanced (NE) and contrast-enhanced (CE) magnetic resonance fingerprinting (MRF) in the prostate gland and to evaluate differences in values among prostate cancer, the normal peripheral zone (PZ) and the normal transition zone (TZ). Fifty-seven patients (median age, 73 years; range, 48-86) with prostate cancer who underwent multiparametric MRI including NE and CE MRF were included in this study. T1 and T2 values were extracted from NE and CE MRF, respectively. Five quantitative values (the ADC, NE T1, NE T2, CE T1 and CE T2 values) were measured in three areas: prostate cancer, PZ and TZ. We compared the values among the three areas and evaluated the differences between NE MRF and CE MRF values. ADC values and MRF-derived values were significantly higher in PZ than prostate cancer or TZ ( < 0.001). TZ had a significantly lower CE T1 but significantly higher values of the other variables than prostate cancer ( < 0.001). The T1 values in all three areas and the T2 values in prostate cancer and TZ were significantly lower on CE MRF than on NE MRF ( < 0.001). Quantitative analysis of NE and CE MRI can be conducted by using the MRF technique. The ADC value and the T1 and T2 values from CE MRF and NE MRF were found to be significantly different between prostate cancer and normal prostate tissue. The T1 and T2 values from contrast-enhanced MR fingerprinting are significantly different between prostate cancer and normal prostate tissue.