Nickel-catalysed cross-electrophile coupling of aryl bromides and primary alkyl bromides

The structure of primary alkylated arenes plays an important role in the molecular action of drugs and natural products. The nickel/spiro-bidentate-pyox catalysed cross-electrophile coupling of aryl bromides and primary alkyl bromides was developed for the formation of the Csp 2 -Csp 3 bond, which p...

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Bibliographic Details
Published in:RSC advances 2022-01, Vol.12 (6), p.3569-3572
Main Authors: Gao, Nanxing, Li, Yanshun, Teng, Dawei
Format: Article
Language:English
Subjects:
Aldehydes
Alkylation
Aromatic compounds
Bromides
Chemistry
Coupling (molecular)
Functional groups
Ketones
Natural products
Nickel
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Summary:The structure of primary alkylated arenes plays an important role in the molecular action of drugs and natural products. The nickel/spiro-bidentate-pyox catalysed cross-electrophile coupling of aryl bromides and primary alkyl bromides was developed for the formation of the Csp 2 -Csp 3 bond, which provided an efficient method for the synthesis of primary alkylated arenes. The reactions could tolerate functional groups such as ester, aldehyde, ketone, ether, benzyl, and imide. The structure of primary alkylated arenes play an important role in the molecular action of drugs and natural products. The nickel/spiro-bidentate-pyox catalysed cross-electrophile coupling of aryl bromides and primary alkyl bromides was developed.
ISSN:2046-2069
2046-2069
DOI:10.1039/d2ra00010e