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Rhabdastrenones A-D from the sponge Rhabdastrella globostellata

Three new isomalabaricanes (1-3), a new α-pyrone derivative (4), together with four known isomalabaricane analogs rhabdastrellin G (5), isogeoditin A (6), stelliferin A (7), and (13 )-isogeoditin A (8) were isolated from the marine sponge . Their chemical structures were determined by HR-ESI-MS, 1D...

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Bibliographic Details
Published in:RSC advances 2022-03, Vol.12 (17), p.10646-10652
Main Authors: Trang, Do Thi, Hang, Dan Thi Thuy, Dung, Duong Thi, Cuc, Nguyen Thi, Yen, Pham Hai, Huong, Phan Thi Thanh, Huyen, Le Thi, Mai, Nguyen Thi, Nhiem, Nguyen Xuan, Tai, Bui Huu, Van Kiem, Phan
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Language:English
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Summary:Three new isomalabaricanes (1-3), a new α-pyrone derivative (4), together with four known isomalabaricane analogs rhabdastrellin G (5), isogeoditin A (6), stelliferin A (7), and (13 )-isogeoditin A (8) were isolated from the marine sponge . Their chemical structures were determined by HR-ESI-MS, 1D and 2D-NMR spectroscopic data analysis. The absolute configurations were identified by Mo (OAc) induced ECD spectra and TD-DFT theoretical calculated ECD spectra. Compound 6 exhibited weak cytotoxic effects against HepG2 and SKMel2 cell lines with the IC values of 7.53 ± 0.70 and 9.93 ± 0.95 μM, respectively.
ISSN:2046-2069
2046-2069
DOI:10.1039/d2ra01674e