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Rhabdastrenones A-D from the sponge Rhabdastrella globostellata
Three new isomalabaricanes (1-3), a new α-pyrone derivative (4), together with four known isomalabaricane analogs rhabdastrellin G (5), isogeoditin A (6), stelliferin A (7), and (13 )-isogeoditin A (8) were isolated from the marine sponge . Their chemical structures were determined by HR-ESI-MS, 1D...
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Published in: | RSC advances 2022-03, Vol.12 (17), p.10646-10652 |
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Main Authors: | , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Three new isomalabaricanes (1-3), a new α-pyrone derivative (4), together with four known isomalabaricane analogs rhabdastrellin G (5), isogeoditin A (6), stelliferin A (7), and (13
)-isogeoditin A (8) were isolated from the marine sponge
. Their chemical structures were determined by HR-ESI-MS, 1D and 2D-NMR spectroscopic data analysis. The absolute configurations were identified by Mo
(OAc)
induced ECD spectra and TD-DFT theoretical calculated ECD spectra. Compound 6 exhibited weak cytotoxic effects against HepG2 and SKMel2 cell lines with the IC
values of 7.53 ± 0.70 and 9.93 ± 0.95 μM, respectively. |
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ISSN: | 2046-2069 2046-2069 |
DOI: | 10.1039/d2ra01674e |