Tackling neurodegenerative diseases with genomic engineering: A new stem cell initiative from the NIH

The iPSC Neurodegenerative Disease Initiative (iNDI) is the largest-ever iPSC genome engineering project. iNDI will model more than 100 mutations associated with Alzheimer's disease and related dementias (ADRD) in isogenic iPSC lines. Resulting cell lines and phenotypic datasets will be broadly...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2021-04, Vol.109 (7), p.1080-1083
Main Authors: Ramos, Daniel M, Skarnes, William C, Singleton, Andrew B, Cookson, Mark R, Ward, Michael E
Format: Article
Language:English
Subjects:
Alzheimer Disease - therapy
Alzheimer's disease
Amyotrophic lateral sclerosis
Biology
Cell lines
CRISPR
Datasets
Dementia
Engineering
Genes
Genetic Engineering - methods
Genome editing
Genomes
Genomics
Humans
Induced Pluripotent Stem Cells - transplantation
Initiatives
Laboratories
Mutation
Neural Stem Cells - transplantation
Neurodegenerative diseases
Neurodegenerative Diseases - genetics
Neurodegenerative Diseases - therapy
Parkinson's disease
Patients
Stem Cell Research
Stem Cell Transplantation
Stem cells
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Summary:The iPSC Neurodegenerative Disease Initiative (iNDI) is the largest-ever iPSC genome engineering project. iNDI will model more than 100 mutations associated with Alzheimer's disease and related dementias (ADRD) in isogenic iPSC lines. Resulting cell lines and phenotypic datasets will be broadly shared.
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2021.03.022