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Tackling neurodegenerative diseases with genomic engineering: A new stem cell initiative from the NIH

The iPSC Neurodegenerative Disease Initiative (iNDI) is the largest-ever iPSC genome engineering project. iNDI will model more than 100 mutations associated with Alzheimer's disease and related dementias (ADRD) in isogenic iPSC lines. Resulting cell lines and phenotypic datasets will be broadly...

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Published in:	Neuron (Cambridge, Mass.) Mass.), 2021-04, Vol.109 (7), p.1080-1083
Main Authors:	Ramos, Daniel M, Skarnes, William C, Singleton, Andrew B, Cookson, Mark R, Ward, Michael E
Format:	Article
Language:	English
Subjects:	Alzheimer Disease - therapy Alzheimer's disease Amyotrophic lateral sclerosis Biology Cell lines CRISPR Datasets Dementia Engineering Genes Genetic Engineering - methods Genome editing Genomes Genomics Humans Induced Pluripotent Stem Cells - transplantation Initiatives Laboratories Mutation Neural Stem Cells - transplantation Neurodegenerative diseases Neurodegenerative Diseases - genetics Neurodegenerative Diseases - therapy Parkinson's disease Patients Stem Cell Research Stem Cell Transplantation Stem cells
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description	The iPSC Neurodegenerative Disease Initiative (iNDI) is the largest-ever iPSC genome engineering project. iNDI will model more than 100 mutations associated with Alzheimer's disease and related dementias (ADRD) in isogenic iPSC lines. Resulting cell lines and phenotypic datasets will be broadly shared.
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subjects	Alzheimer Disease - therapy Alzheimer's disease Amyotrophic lateral sclerosis Biology Cell lines CRISPR Datasets Dementia Engineering Genes Genetic Engineering - methods Genome editing Genomes Genomics Humans Induced Pluripotent Stem Cells - transplantation Initiatives Laboratories Mutation Neural Stem Cells - transplantation Neurodegenerative diseases Neurodegenerative Diseases - genetics Neurodegenerative Diseases - therapy Parkinson's disease Patients Stem Cell Research Stem Cell Transplantation Stem cells
title	Tackling neurodegenerative diseases with genomic engineering: A new stem cell initiative from the NIH
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