Microneedle-based nanoporous gold electrochemical sensor for real-time catecholamine detection

Dopamine (DA), epinephrine (EP), and norepinephrine (NEP) are the main catecholamine of clinical interest, as they play crucial roles in the regulation of nervous and cardiovascular systems and are involved in some brain behaviors, such as stress, panic, anxiety, and depression. Therefore, there is...

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Bibliographic Details
Published in:Mikrochimica acta (1966) 2022-05, Vol.189 (5), p.180-180, Article 180
Main Authors: Tortolini, Cristina, Cass, Anthony E. G., Pofi, Riccardo, Lenzi, Andrea, Antiochia, Riccarda
Format: Article
Language:English
Subjects:
Ammonium chloride
Analysis
Analytical Chemistry
Anxiety
Catecholamine
Catecholamines
Characterization and Evaluation of Materials
Chemical sensors
Chemistry
Chemistry and Materials Science
Depression, Mental
Dopamine
Electrochemical reactions
Electrodes
Epinephrine
Gold
Hydrogels
Laws, regulations and rules
Microengineering
Monitoring
Nanochemistry
Nanopores
Nanotechnology
Needles
Norepinephrine
Original Paper
Response time
Sensor arrays
Sensors
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Summary:Dopamine (DA), epinephrine (EP), and norepinephrine (NEP) are the main catecholamine of clinical interest, as they play crucial roles in the regulation of nervous and cardiovascular systems and are involved in some brain behaviors, such as stress, panic, anxiety, and depression. Therefore, there is an urgent need for a reliable sensing device able to provide their continuous monitoring in a minimally invasive manner. In this work, the first highly nanoporous gold (h-nPG) microneedle-based sensor is presented for continuous monitoring of catecholamine in interstitial fluid (ISF). The h-nPG microneedle-based gold electrode was prepared by a simple electrochemical self-templating method that involves two steps, gold electrodeposition and hydrogen bubbling at the electrode surface, realized by sweeping the potential between + 0.8 V and 0 V vs Ag/AgCl for 25 scans in a 10 mM HAuCl 4 solution containing 2.5 M NH 4 Cl, and successively applying a fixed potential of − 2 V vs Ag/AgCl for 60 s. The resulting microneedle-based h-nPG sensor displays an interference-free total catecholamine detection expressed as NEP concentration, with a very low LOD of 100 nM, excellent sensitivity and stability, and fast response time (
ISSN:0026-3672
1436-5073
DOI:10.1007/s00604-022-05260-2