Keratolysis exfoliativa-like eruption induced by ranolazine

Dermatoses affecting palms may represent a dermatologic challenge from both the diagnostic, and therapeutic point of view. Patients with supposedly occupational dermatitis can spend months or even years in a frustrating attempt to avoid contact with possible irritants or allergens. To underline the...

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Bibliographic Details
Published in:Dermatology reports 2022-03, Vol.14 (1)
Main Authors: Pierobon, Elena, Germi, Lerica, Sechi, Andrea, Trevisan, Giampaolo, Pezzolo, Elena, Feliciani, Claudio, Naldi, Luigi
Format: Article
Language:English
Subjects:
Case Report
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Summary:Dermatoses affecting palms may represent a dermatologic challenge from both the diagnostic, and therapeutic point of view. Patients with supposedly occupational dermatitis can spend months or even years in a frustrating attempt to avoid contact with possible irritants or allergens. To underline the importance of a thorough unbiased analysis of the patient’s history and clinical features, we present the iconic case of a bricklayer affected by a chronic, disabling desquamation of palms which in the end was classified as keratolysis exfoliativa (KE) attributed to ranolazine-intake, an antianginal drug. To the best of our knowledge, this specific adverse effect of druginduced KE of palms has never been reported before in association with ranolazine.
ISSN:2036-7392
2036-7406
DOI:10.4081/dr.2022.9264