Multi-activity cobalt ferrite/MXene nanoenzymes for drug-free phototherapy in bacterial infection treatment

Drug-free antibacterial strategies are of great significance for pathogenic bacterial infection treatment in clinical practice. Phototherapy with antibacterial function plays a vital role in mainstream germicidal research. However, phototherapy could lead to residual heat and excess reactive oxygen...

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Bibliographic Details
Published in:RSC advances 2022-04, Vol.12 (18), p.11090-11099
Main Authors: Shi, Jiacheng, Shu, Rui, Shi, Xiuyuan, Li, Yunfei, Li, Jiangge, Deng, Yi, Yang, Weizhong
Format: Article
Language:English
Subjects:
Antiinfectives and antibacterials
Bacteria
Bacterial infections
Biocompatibility
Catalase
Chemistry
Cobalt ferrites
Enzymes
Glutathione
High temperature
Light therapy
MXenes
Peroxidase
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Summary:Drug-free antibacterial strategies are of great significance for pathogenic bacterial infection treatment in clinical practice. Phototherapy with antibacterial function plays a vital role in mainstream germicidal research. However, phototherapy could lead to residual heat and excess reactive oxygen species (ROS), which are the main side-effects during antibacterial treatment. Unique CoFe O /MXene (CM) nanoenzymes, which were fabricated with electrostatic interactions, have been designed to conquer those challenges caused by side-effects of phototherapy in our research. The CM nanoenzymes possess many promising properties including photothermal and photodynamic induced phototherapy and mimic peroxidase (POD), glutathione oxidase (GSHOx), and catalase (CAT). Upon treatment with near-infrared (NIR) light, CM nanoenzymes can create a local high-temperature circumstance as well as raise bacterial membrane permeability. Furthermore, the photodynamic process and multi-enzyme-mimicking activities of CM enzymes boost the interbacterial ROS level. Herein, bacteria can hardly survive in synergistic phototherapy and multi-enzyme-mimicking catalytic therapy and . Meanwhile, the CM nanoenzymes exhibit excellent biocompatibility and . Overall, this research establishes a strong foundation for effectively employing nanoenzymes, leading to a new way to cure bacterial infections.
ISSN:2046-2069
2046-2069
DOI:10.1039/d2ra01133f