Long-term weight changes and risk of rheumatoid arthritis among women in a prospective cohort: a marginal structural model approach

Abstract Objective To examine the association of long-term weight change with RA risk in a large prospective cohort study. Methods The Nurses’ Health Study II started in 1989 (baseline); after exclusions, we studied 108 505 women 25–42 years old without RA. Incident RA was reported by participants a...

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Bibliographic Details
Published in:Rheumatology (Oxford, England) England), 2022-04, Vol.61 (4), p.1430-1439
Main Authors: Marchand, Nathalie E, Sparks, Jeffrey A, Malspeis, Susan, Yoshida, Kazuki, Prisco, Lauren, Zhang, Xuehong, Costenbader, Karen, Hu, Frank, Karlson, Elizabeth W, Lu, Bing
Format: Article
Language:English
Subjects:
Adolescent
Adult
Arthritis, Rheumatoid - epidemiology
Arthritis, Rheumatoid - prevention & control
Clinical Science
Female
Humans
Incidence
Models, Structural
Prospective Studies
Risk Factors
Weight Gain
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Summary:Abstract Objective To examine the association of long-term weight change with RA risk in a large prospective cohort study. Methods The Nurses’ Health Study II started in 1989 (baseline); after exclusions, we studied 108 505 women 25–42 years old without RA. Incident RA was reported by participants and confirmed by medical record review. Body weight was reported biennially through 2015. We investigated two time-varying exposures: weight changes from baseline and from age 18; change was divided into five categories. We used a marginal structural model approach to account for time-varying weight change and covariates. Results Over 2 583 266 person-years, with a median follow-up time of 25.3 years, 541 women developed RA. Compared with women with stable weight from baseline, weight change was significantly associated with increased RA risk [weight gain 2–
ISSN:1462-0324
1462-0332
1462-0332
DOI:10.1093/rheumatology/keab535