In Vivo and In Vitro Cartilage Differentiation from Embryonic Epicardial Progenitor Cells

The presence of cartilage tissue in the embryonic and adult hearts of different vertebrate species is a well-recorded fact. However, while the embryonic neural crest has been historically considered as the main source of cardiac cartilage, recently reported results on the wide connective potential o...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-03, Vol.23 (7), p.3614
Main Authors: Palmquist-Gomes, Paul, Marín-Sedeño, Ernesto, Ruiz-Villalba, Adrián, Rico-Llanos, Gustavo Adolfo, Pérez-Pomares, José María, Guadix, Juan Antonio
Format: Article
Language:English
Subjects:
Cartilage
Cell differentiation
Cell Differentiation - physiology
Cells (biology)
Chondrocytes
Connective tissue
Coronary vessels
Embryonic Stem Cells
Embryos
Fibroblasts
Heart
Neural Crest
Neural stem cells
Pericardium
Progenitor cells
Smooth muscle
Vertebrates
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Summary:The presence of cartilage tissue in the embryonic and adult hearts of different vertebrate species is a well-recorded fact. However, while the embryonic neural crest has been historically considered as the main source of cardiac cartilage, recently reported results on the wide connective potential of epicardial lineage cells suggest they could also differentiate into chondrocytes. In this work, we describe the formation of cardiac cartilage clusters from proepicardial cells, both in vivo and in vitro. Our findings report, for the first time, cartilage formation from epicardial progenitor cells, and strongly support the concept of proepicardial cells as multipotent connective progenitors. These results are relevant to our understanding of cardiac cell complexity and the responses of cardiac connective tissues to pathologic stimuli.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23073614