p120‐catenin is required for regulating epidermal proliferation, differentiation, and barrier function

p120‐catenin (p120) is an important regulator in the function and stability of E‐cadherin. However, the role of p120 in the epidermis is unclear. Previous studies have shown that globally knockout of p120 caused increased epidermal proliferation but little changes in epidermal differentiation and pe...

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Bibliographic Details
Published in:Journal of cellular physiology 2019-01, Vol.234 (1), p.427-432
Main Authors: Xie, Zhongjian, Tang, Yuanyuan, Man, Mao‐Qiang, Shrestha, Chandrama, Bikle, Daniel D.
Format: Article
Language:English
Subjects:
Animals
barrier function
Cadherins - genetics
Catenin
Catenins - genetics
Cell Differentiation - genetics
Cell Membrane Permeability - genetics
Cell Proliferation - genetics
Differentiation
E-cadherin
Epidermal Cells - metabolism
Epidermal Cells - pathology
Epidermis
Epidermis - growth & development
Epidermis - metabolism
Epidermis - pathology
Humans
Mice
Mice, Knockout
p120‐catenin
Permeability
proliferation
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Summary:p120‐catenin (p120) is an important regulator in the function and stability of E‐cadherin. However, the role of p120 in the epidermis is unclear. Previous studies have shown that globally knockout of p120 caused increased epidermal proliferation but little changes in epidermal differentiation and permeability. In the present study, we generated a conditional knockout mouse model and examined epidermal proliferation, differentiation and permeability. The results showed that conditional knockout of p120 in the epidermis caused not only increased epidermal proliferation but also decreased epidermal differentiation and increased permeability. These data suggest that p120 is required for suppressing epidermal proliferation, promoting epidermal differentiation and maintaining permeability barrier function of the epidermis. The results from keratinocyte specific p120cKO in adult mice showed that epidermal differentiation and permeability barrier function were reduced and proliferation was enhanced. These data suggest that p120 is required for promoting epidermal differentiation and permeability barrier function and suppressing epidermal proliferation most likely by its critical role in the maintenance of the E‐cadherin/catenin complex.
ISSN:0021-9541
1097-4652
DOI:10.1002/jcp.26535