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The role of GABAergic signalling in neurodevelopmental disorders
GABAergic inhibition shapes the connectivity, activity and plasticity of the brain. A series of exciting new discoveries provides compelling evidence that disruptions in a number of key facets of GABAergic inhibition have critical roles in the aetiology of neurodevelopmental disorders (NDDs). These...
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| Published in: | Nature reviews. Neuroscience 2021-05, Vol.22 (5), p.290-307 |
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| container_title | Nature reviews. Neuroscience |
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| creator | Tang, Xin Jaenisch, Rudolf Sur, Mriganka |
| description | GABAergic inhibition shapes the connectivity, activity and plasticity of the brain. A series of exciting new discoveries provides compelling evidence that disruptions in a number of key facets of GABAergic inhibition have critical roles in the aetiology of neurodevelopmental disorders (NDDs). These facets include the generation, migration and survival of GABAergic neurons, the formation of GABAergic synapses and circuit connectivity, and the dynamic regulation of the efficacy of GABAergic signalling through neuronal chloride transporters. In this Review, we discuss recent work that elucidates the functions and dysfunctions of GABAergic signalling in health and disease, that uncovers the contribution of GABAergic neural circuit dysfunction to NDD aetiology and that leverages such mechanistic insights to advance precision medicine for the treatment of NDDs.
Dysfunctional GABAergic signalling is common to various neurodevelopmental disorders (NDDs). Tang, Jaenisch and Sur give an overview of the contribution of GABA signalling dysfunction to NDD aetiology and examine how mechanistic insights into such disruption can be used to advance treatments for NDDs. |
| doi_str_mv | 10.1038/s41583-021-00443-x |
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Dysfunctional GABAergic signalling is common to various neurodevelopmental disorders (NDDs). Tang, Jaenisch and Sur give an overview of the contribution of GABA signalling dysfunction to NDD aetiology and examine how mechanistic insights into such disruption can be used to advance treatments for NDDs.</description><identifier>ISSN: 1471-003X</identifier><identifier>EISSN: 1471-0048</identifier><identifier>EISSN: 1469-3178</identifier><identifier>DOI: 10.1038/s41583-021-00443-x</identifier><identifier>PMID: 33772226</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/378/1689/2608 ; 631/378/87 ; Animal Genetics and Genomics ; Behavioral Sciences ; Biological Techniques ; Biomedical and Life Sciences ; Biomedicine ; Causes of ; Cellular signal transduction ; Child development deviations ; Development and progression ; Developmental disabilities ; Etiology ; GABA ; GABAergic Neurons ; gamma-Aminobutyric Acid ; Genetic aspects ; Health aspects ; Humans ; Nerve Net - physiopathology ; Nervous system diseases ; Neural circuitry ; Neural networks ; Neurobiology ; Neurodevelopmental disorders ; Neurodevelopmental Disorders - physiopathology ; Neurodevelopmental Disorders - therapy ; Neuroplasticity ; Neurosciences ; Precision Medicine ; Review Article ; Signal Transduction ; Synapses ; Synaptogenesis ; γ-Aminobutyric acid</subject><ispartof>Nature reviews. Neuroscience, 2021-05, Vol.22 (5), p.290-307</ispartof><rights>Springer Nature Limited 2021</rights><rights>COPYRIGHT 2021 Nature Publishing Group</rights><rights>Springer Nature Limited 2021.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c541t-70b42286f218710e9bfd421908a89f3c5dc15a84715226159b2d4d66b02642e43</citedby><cites>FETCH-LOGICAL-c541t-70b42286f218710e9bfd421908a89f3c5dc15a84715226159b2d4d66b02642e43</cites><orcidid>0000-0002-2540-7099 ; 0000-0003-2442-5671</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33772226$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tang, Xin</creatorcontrib><creatorcontrib>Jaenisch, Rudolf</creatorcontrib><creatorcontrib>Sur, Mriganka</creatorcontrib><title>The role of GABAergic signalling in neurodevelopmental disorders</title><title>Nature reviews. Neuroscience</title><addtitle>Nat Rev Neurosci</addtitle><addtitle>Nat Rev Neurosci</addtitle><description>GABAergic inhibition shapes the connectivity, activity and plasticity of the brain. A series of exciting new discoveries provides compelling evidence that disruptions in a number of key facets of GABAergic inhibition have critical roles in the aetiology of neurodevelopmental disorders (NDDs). These facets include the generation, migration and survival of GABAergic neurons, the formation of GABAergic synapses and circuit connectivity, and the dynamic regulation of the efficacy of GABAergic signalling through neuronal chloride transporters. In this Review, we discuss recent work that elucidates the functions and dysfunctions of GABAergic signalling in health and disease, that uncovers the contribution of GABAergic neural circuit dysfunction to NDD aetiology and that leverages such mechanistic insights to advance precision medicine for the treatment of NDDs.
Dysfunctional GABAergic signalling is common to various neurodevelopmental disorders (NDDs). Tang, Jaenisch and Sur give an overview of the contribution of GABA signalling dysfunction to NDD aetiology and examine how mechanistic insights into such disruption can be used to advance treatments for NDDs.</description><subject>631/378/1689/2608</subject><subject>631/378/87</subject><subject>Animal Genetics and Genomics</subject><subject>Behavioral Sciences</subject><subject>Biological Techniques</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Causes of</subject><subject>Cellular signal transduction</subject><subject>Child development deviations</subject><subject>Development and progression</subject><subject>Developmental disabilities</subject><subject>Etiology</subject><subject>GABA</subject><subject>GABAergic Neurons</subject><subject>gamma-Aminobutyric Acid</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Nerve Net - physiopathology</subject><subject>Nervous system diseases</subject><subject>Neural circuitry</subject><subject>Neural networks</subject><subject>Neurobiology</subject><subject>Neurodevelopmental disorders</subject><subject>Neurodevelopmental Disorders - physiopathology</subject><subject>Neurodevelopmental Disorders - therapy</subject><subject>Neuroplasticity</subject><subject>Neurosciences</subject><subject>Precision Medicine</subject><subject>Review Article</subject><subject>Signal Transduction</subject><subject>Synapses</subject><subject>Synaptogenesis</subject><subject>γ-Aminobutyric acid</subject><issn>1471-003X</issn><issn>1471-0048</issn><issn>1469-3178</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9UU1rFTEUDaLYWv0DLmTAjZup-Z7MRnwWbYWCmwruQia5M03JJM_kTan_3ry--tqKSAL5Oufk3HsQek3wMcFMvS-cCMVaTEmLMeesvXmCDgnvbo_q6X7PfhygF6VcYUwk6eRzdMBY11FK5SH6eHEJTU4BmjQ2p6tPK8iTt03xUzQh-Dg1PjYRlpwcXENI6xnixoTG-ZKyg1xeomejCQVe3a1H6PuXzxcnZ-35t9OvJ6vz1gpONm2HB06pkiMlqiMY-mF0nJIeK6P6kVnhLBFGVcOi-iKiH6jjTsoBU8kpcHaEPux018swg7PVRjZBr7OfTf6lk_H68Uv0l3pK17qvZRMhq8C7O4Gcfi5QNnr2xUIIJkJaiqYCS9pJSmiFvv0LepWWXBuyRZFqn9V5j5pMAO3jmOq_diuqV1L0XFEqREUd_wNVh4PZ2xRh9PX-EYHuCDanUjKM-xoJ1tvc9S53XXPXt7nrm0p687A7e8qfoCuA7QClPsUJ8n1J_5H9DWI3thc</recordid><startdate>20210501</startdate><enddate>20210501</enddate><creator>Tang, Xin</creator><creator>Jaenisch, Rudolf</creator><creator>Sur, Mriganka</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2540-7099</orcidid><orcidid>https://orcid.org/0000-0003-2442-5671</orcidid></search><sort><creationdate>20210501</creationdate><title>The role of GABAergic signalling in neurodevelopmental disorders</title><author>Tang, Xin ; Jaenisch, Rudolf ; Sur, Mriganka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c541t-70b42286f218710e9bfd421908a89f3c5dc15a84715226159b2d4d66b02642e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>631/378/1689/2608</topic><topic>631/378/87</topic><topic>Animal Genetics and Genomics</topic><topic>Behavioral Sciences</topic><topic>Biological Techniques</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Causes of</topic><topic>Cellular signal transduction</topic><topic>Child development deviations</topic><topic>Development and progression</topic><topic>Developmental disabilities</topic><topic>Etiology</topic><topic>GABA</topic><topic>GABAergic Neurons</topic><topic>gamma-Aminobutyric Acid</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Nerve Net - physiopathology</topic><topic>Nervous system diseases</topic><topic>Neural circuitry</topic><topic>Neural networks</topic><topic>Neurobiology</topic><topic>Neurodevelopmental disorders</topic><topic>Neurodevelopmental Disorders - physiopathology</topic><topic>Neurodevelopmental Disorders - therapy</topic><topic>Neuroplasticity</topic><topic>Neurosciences</topic><topic>Precision Medicine</topic><topic>Review Article</topic><topic>Signal Transduction</topic><topic>Synapses</topic><topic>Synaptogenesis</topic><topic>γ-Aminobutyric acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tang, Xin</creatorcontrib><creatorcontrib>Jaenisch, Rudolf</creatorcontrib><creatorcontrib>Sur, Mriganka</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>ProQuest Biological Science Journals</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nature reviews. Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tang, Xin</au><au>Jaenisch, Rudolf</au><au>Sur, Mriganka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of GABAergic signalling in neurodevelopmental disorders</atitle><jtitle>Nature reviews. Neuroscience</jtitle><stitle>Nat Rev Neurosci</stitle><addtitle>Nat Rev Neurosci</addtitle><date>2021-05-01</date><risdate>2021</risdate><volume>22</volume><issue>5</issue><spage>290</spage><epage>307</epage><pages>290-307</pages><issn>1471-003X</issn><eissn>1471-0048</eissn><eissn>1469-3178</eissn><abstract>GABAergic inhibition shapes the connectivity, activity and plasticity of the brain. A series of exciting new discoveries provides compelling evidence that disruptions in a number of key facets of GABAergic inhibition have critical roles in the aetiology of neurodevelopmental disorders (NDDs). These facets include the generation, migration and survival of GABAergic neurons, the formation of GABAergic synapses and circuit connectivity, and the dynamic regulation of the efficacy of GABAergic signalling through neuronal chloride transporters. In this Review, we discuss recent work that elucidates the functions and dysfunctions of GABAergic signalling in health and disease, that uncovers the contribution of GABAergic neural circuit dysfunction to NDD aetiology and that leverages such mechanistic insights to advance precision medicine for the treatment of NDDs.
Dysfunctional GABAergic signalling is common to various neurodevelopmental disorders (NDDs). Tang, Jaenisch and Sur give an overview of the contribution of GABA signalling dysfunction to NDD aetiology and examine how mechanistic insights into such disruption can be used to advance treatments for NDDs.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>33772226</pmid><doi>10.1038/s41583-021-00443-x</doi><tpages>18</tpages><orcidid>https://orcid.org/0000-0002-2540-7099</orcidid><orcidid>https://orcid.org/0000-0003-2442-5671</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 631/378/1689/2608 631/378/87 Animal Genetics and Genomics Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Causes of Cellular signal transduction Child development deviations Development and progression Developmental disabilities Etiology GABA GABAergic Neurons gamma-Aminobutyric Acid Genetic aspects Health aspects Humans Nerve Net - physiopathology Nervous system diseases Neural circuitry Neural networks Neurobiology Neurodevelopmental disorders Neurodevelopmental Disorders - physiopathology Neurodevelopmental Disorders - therapy Neuroplasticity Neurosciences Precision Medicine Review Article Signal Transduction Synapses Synaptogenesis γ-Aminobutyric acid |
| title | The role of GABAergic signalling in neurodevelopmental disorders |
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