Clinical Evidence of Effects of Green Mandarin (Putgyul) Extract on Skin Aging: A Randomized, Double Blind, Placebo-Controlled Study

Green mandarins are widely consumed unripe as mandarin oranges ( ), which exhibit anti-inflammatory and anti-wrinkle effects by inhibiting the production of inflammatory cytokines and matrix metalloproteinase. A randomized, double-blind, placebo-controlled clinical study was performed to verify the...

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Bibliographic Details
Published in:Nutrients 2022-03, Vol.14 (7), p.1352
Main Authors: Ham, Young-Min, Yoon, Seon-A, Hyeon, Hyejin, Hyun, Ho-Bong, Kim, Sung-Chun, Go, Boram, Jung, Yong-Hwan, Yoon, Weon-Jong
Format: Article
Language:English
Subjects:
Aging
Antioxidants
Citrus
Citrus fruits
Clinical trials
Collagen
Cytokines
Double-Blind Method
Double-blind studies
Enzymes
Erythema
Ethanol
Flavonoids
Food
Functional foods & nutraceuticals
Gloss
Humans
Inflammation
Kinases
Mandarins
Matrix metalloproteinase
Matrix metalloproteinases
Metalloproteinase
Moisture content
Oral administration
Placebos
Plant Extracts - therapeutic use
Skin
Skin Aging
Standardization
Steroids
Water content
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Summary:Green mandarins are widely consumed unripe as mandarin oranges ( ), which exhibit anti-inflammatory and anti-wrinkle effects by inhibiting the production of inflammatory cytokines and matrix metalloproteinase. A randomized, double-blind, placebo-controlled clinical study was performed to verify the skin improvement efficacy and safety of green mandarin extract (PTE). For the standardization of PTE, narirutin was set as a marker compound, and PTE with a constant narirutin content was prepared for the study. After randomizing subjects with periorbital wrinkles, they were orally administered PTE (300 mg/day) or a placebo for 12 weeks. Periorbital wrinkles were measured using PRIMOS SF. Skin elasticity, moisture content, transepidermal water loss, and gloss were also measured. In the study results, the depth, volume, and skin roughness of the periorbital wrinkles were significantly improved compared to the control group ( = 0.011, 0.009, and 0.004, respectively). The survey confirmed that the skin condition improved after PTE consumption for 12 weeks. No adverse reactions associated with PTE were observed during the study period. Thus, the results demonstrate that PTE effectively improves UV-induced skin wrinkles. Therefore, it is considered that PTE has sufficient value as a functional food ingredient that can prevent skin aging.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu14071352