115 Effects of a Chronic Lipopolysaccharide Challenge on Growth Performance and Immune Response of Nursery Pigs Fed Differing Sources of Dietary Zinc

• Published in: Journal of animal science 2022-04, Vol.100 (Supplement_2), p.52-53
• Main Authors: Harshman, Jared A, Carter, Scott D, Aparachita, Pornpim, Scaff, Taw, van de Ligt, Chris
• Format: Article
• Language: English
• ISSN: 0021-8812; 1525-3163
• DOI: 10.1093/jas/skac064.083

Two experiments were conducted to determine the effects of zinc source on growth performance and immune response during a chronic lipopolysaccharide (LPS) challenge. Each study utilized 180 pigs (5.2 kg, 18-21 d) in a 42-d experiment. Pigs were allocated to pens (10 pigs/pen; 5 pens/trt) and pens were randomly assigned to 4 treatments on d 0. Three dietary treatments consisted of the addition of 100 ppm of added zinc from 3 sources (ZnHydroxyCl, ZnSO4, and ZnO). On d 29, 31, 33 and 35 of the study, challenged pigs were injected intramuscularly with LPS (10 ug/kg BW). Additionally, a control group was fed ZnHydroxyCl without receiving LPS. Pigs and feeders were weighed to determine ADG, ADFI, and G:F. Blood samples, BW, and rectal temperature (RT) were taken before the first LPS injection and 3 h post-injection on d 36. Data were analyzed using the MIXED procedure in SAS with pen as the experimental unit. There were no experiment by treatment interactions (P > 0.10). Prior to LPS challenge (d 0–28), there were no effects (P > 0.10) of treatment on ADG, ADFI, or G:F. Pigs receiving LPS had lower G:F, and greater RT and TNF-α during d 28-36 compared with non-challenged pigs (P < 0.01). Within the LPS-challenged pigs, there was no difference (P > 0.10) in ADG or ADFI among treatments (d 28-36, 0-42); however, pigs fed ZnHydroxyCl were more efficient (P < 0.02). RT and TNF-α at h 0 were similar (P > 0.10) among treatments. On d 36, 3 h following the last LPS injection, pigs fed ZnHydroxyCl had lower RT and TNF-α, followed by ZnO, then ZnSO4 (P < 0.10.) These data suggest that of the sources fed, pigs fed ZnHydroxyCl had greater performance and a lower immune response during a health challenge.