Application of chitosan/alginate nanoparticle in oral drug delivery systems: prospects and challenges

Oral drug delivery systems (ODDSs) have various advantages of simple operation and few side effects. ODDSs are highly desirable for colon-targeted therapy (e.g. ulcerative colitis and colorectal cancer), as they improve therapeutic efficiency and reduce systemic toxicity. Chitosan/alginate nanoparti...

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Bibliographic Details
Published in:Drug delivery 2022-12, Vol.29 (1), p.1142-1149
Main Authors: Li, Shangyong, Zhang, Hui, Chen, Kaiwei, Jin, Mengfei, Vu, Son Hai, Jung, Samil, He, Ningning, Zheng, Zhou, Lee, Myeong-Sok
Format: Article
Language:English
Subjects:
Administration, Oral
Alginates
Biocompatibility
Cancer therapies
Chitosan
chitosan/alginate nanoparticle
Colitis, Ulcerative - drug therapy
colon cancer
Colorectal cancer
Disease
Drug Carriers - therapeutic use
Drug Delivery Systems
Drugs
Efficiency
Environmental science
Fecal incontinence
Humans
Inflammatory bowel disease
Insulin
Laboratories
Methods
Nanoparticles
Oceanography
Oral drug delivery
Particle size
Pharmaceutical Preparations
Polymers
ulcerative colitis
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Summary:Oral drug delivery systems (ODDSs) have various advantages of simple operation and few side effects. ODDSs are highly desirable for colon-targeted therapy (e.g. ulcerative colitis and colorectal cancer), as they improve therapeutic efficiency and reduce systemic toxicity. Chitosan/alginate nanoparticles (CANPs) show strong electrostatic interaction between the carboxyl group of alginates and the amino group of chitosan which leads to shrinkage and gel formation at low pH, thereby protecting the drugs from the gastrointestinal tract (GIT) and aggressive gastric environment. Meanwhile, CANPs as biocompatible polymer, show intestinal mucosal adhesion, which could extend the retention time of drugs on inflammatory sites. Recently, CANPs have attracted increasing interest as colon-targeted oral drug delivery system for intestinal diseases. The purpose of this review is to summarize the application and treatment of CANPs in intestinal diseases and insulin delivery. And then provide a future perspective of the potential and development direction of CANPs as colon-targeted ODDSs.
ISSN:1071-7544
1521-0464
DOI:10.1080/10717544.2022.2058646