Home mortgage discrimination and incidence of triple-negative and Luminal A breast cancer among non-Hispanic Black and non-Hispanic White females in California, 2006–2015

• Published in: Cancer causes & control 2022-05, Vol.33 (5), p.727-735
• Main Authors: Michaels, Eli K., Canchola, Alison J., Beyer, Kirsten M. M., Zhou, Yuhong, Shariff-Marco, Salma, Gomez, Scarlett L.
• Format: Article
• Language: English
• Subjects: Bias; Biomedical and Life Sciences; Biomedicine; Black or African American; Breast cancer; California - epidemiology; Cancer Research; Census; Censuses; Cross-Sectional Studies; Discrimination; Epidemiology; Female; Females; Health Status Disparities; Hematology; Hispanic people; Humans; Incidence; Invasiveness; Metropolitan areas; Minority & ethnic groups; Neighborhoods; Oncology; Original Paper; Public Health; Racism; Triple Negative Breast Neoplasms - epidemiology; United States
• ISSN: 0957-5243; 1573-7225
• DOI: 10.1007/s10552-022-01557-y

Purpose In the United States, Black females are burdened by more aggressive subtypes and increased mortality from breast cancer compared to non-Hispanic (NH) White females. Institutional racism may contribute to these inequities. We aimed to characterize the association between home mortgage discrimination, a novel measure of institutional racism, and incidence of Luminal A and triple-negative breast cancer (TNBC) subtypes among NH Black and NH White females in California metropolitan areas. Methods We merged data from the California Cancer Registry on females aged 20 + diagnosed with primary invasive breast cancer between 2006 and 2015 with a census tract-level index of home mortgage lending bias measuring the odds of mortgage loan denial for Black versus White applicants, generated from the 2007–2013 Home Mortgage Disclosure Act database. Poisson regression estimated cross-sectional associations of census tract-level racial bias in mortgage lending with race/ethnicity- and Luminal A and TNBC-specific incidence rate ratios, adjusting for neighborhood confounders. Results We identified n  = 102,853 cases of Luminal A and n  = 15,528 cases of TNBC over the study period. Compared to NH Whites, NH Black females had higher rates of TNBC, lower rates of Luminal A breast cancer, and lived in census tracts with less racial bias in home mortgage lending. There was no evidence of association between neighborhood racial bias in mortgage lending at the time of diagnosis and either subtype among either racial/ethnic group. Conclusion Future research should incorporate residential history data with measures of institutional racism to improve estimation and inform policy interventions.