In vitro activity of trovafloxacin compared to those of five antimicrobials against mycoplasmas including Mycoplasma hominis and Ureaplasma urealyticum fluoroquinolone-resistant isolates that have been genetically characterized

The in vitro activity of trovafloxacin against 125 strains of Mycoplasma species and Ureaplasma urealyticum, including fluoroquinolone-susceptible and fluoroquinolone-resistant species, was compared to those of other fluoroquinolones, doxycycline, and erythromycin. The MIC at which 90% of isolates a...

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Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 2000-09, Vol.44 (9), p.2557-2560
Main Authors: BEBEAR, C. M, RENAUDIN, H, CHARRON, A, GRUSON, D, LEFRANCOIS, M, BEBEAR, C
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacteriology
Biological and medical sciences
Ciprofloxacin - pharmacology
Doxycycline - pharmacology
Drug Resistance, Microbial - genetics
Erythromycin - pharmacology
Fluoroquinolones
Fundamental and applied biological sciences. Psychology
Genetics
Humans
Medical sciences
Microbial Sensitivity Tests
Microbiology
Mycoplasma hominis
Mycoplasma hominis - drug effects
Mycoplasma hominis - genetics
Mycoplasma hominis - isolation & purification
Naphthyridines - pharmacology
Ofloxacin - pharmacology
Pharmacology. Drug treatments
Susceptibility
Ureaplasma urealyticum
Ureaplasma urealyticum - drug effects
Ureaplasma urealyticum - genetics
Ureaplasma urealyticum - isolation & purification
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Summary:The in vitro activity of trovafloxacin against 125 strains of Mycoplasma species and Ureaplasma urealyticum, including fluoroquinolone-susceptible and fluoroquinolone-resistant species, was compared to those of other fluoroquinolones, doxycycline, and erythromycin. The MIC at which 90% of isolates are inhibited for all fluoroquinolone-susceptible strains was 0.25 microg/ml. Whatever the associated mutations, trovafloxacin exhibited greater activity than the other fluoroquinolones tested against fluoroquinolone-resistant Mycoplasma hominis and U. urealyticum isolates.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.44.9.2557-2560.2000