Self-adhesive hydrogel meshes reduce tissue incorporation and mechanical behavior versus microgrips self-fixation: a preclinical study

• Published in: Hernia : the journal of hernias and abdominal wall surgery 2022-04, Vol.26 (2), p.543-555
• Main Authors: Benito-Martínez, Selma, Rodríguez, Marta, García-Moreno, Francisca, Pérez-Köhler, Bárbara, Peña, Estefanía, Calvo, Begoña, Pascual, Gemma, Bellón, Juan Manuel
• Format: Article
• Language: English
• Subjects: Abdomen; Abdominal Surgery; Abdominal wall; Adhesives; Animals; Chronic pain; Cyanoacrylates; Experimental hernia surgery; Hernia; Hernia, Abdominal - surgery; Hernias; Herniorrhaphy; Humans; Hydrogels; Macrophages; Mechanical properties; Medicine; Medicine & Public Health; Original; Original Article; Polypropylene; Polypropylenes; Rabbits; Resin Cements; Surgical Mesh; tissue engineering and biomaterial research in hernia repair
• ISSN: 1265-4906; 1248-9204
• DOI: 10.1007/s10029-021-02552-z

Purpose Atraumatic mesh fixation for abdominal hernia repair has been developed to avoid the disadvantages of classical fixation with sutures, which is considered a cause of chronic pain and discomfort. This study was designed to analyze, in the short and medium term, the biological and mechanical behavior of two self-fixing meshes compared to that of a polypropylene (PP) mesh fixed with a cyanoacrylate (CA) tissue adhesive. Methods Partial abdominal wall defects (6 × 4 cm) were created in New Zealand rabbits ( n  = 36) and repaired using a self-adhesive hydrogel mesh (Adhesix™), a self-gripping mesh (ProGrip™) or a PP mesh fixed with CA (Surgipro™ CA). After 14 and 90 days, the host tissue incorporation, macrophage response and biomechanical strength were examined. Results At 14 and 90 days, the ProGrip and Surgipro CA meshes showed good host tissue incorporation; however, the Adhesix implants presented poor integration, seroma formation and a higher degree of shrinkage. The Adhesix hydrogel was completely reabsorbed at 14 days, whereas ProGrip microhooks were observed at all study times. The macrophage response was higher in the ProGrip and Surgipro CA groups at 14 and 90 days, respectively, and decreased over time. At 90 days, the ProGrip implants showed the highest tensile strength values and the Adhesix implants showed the highest failure stretch. Conclusion Meshes with mechanical microgrip self-fixation (ProGrip) show better biological and mechanical behavior than those with adhesive hydrogel (Adhesix) in a preclinical model of abdominal hernia repair in rabbits.