Exploration on the Effect of Nonselective β-Receptor Blockers (NSBBs) on Hemodynamic Parameters in Complicated Liver Cirrhosis

Esophageal-gastric variceal bleeding occurs in 5–15% of patients with liver cirrhosis annually, and the mortality rate is as high as 20% within 6 weeks of the first bleed. The more compromised the liver function, the higher the mortality. Effective control of bleeding is pivotal for reducing mortali...

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Bibliographic Details
Published in:BioMed research international 2022, Vol.2022 (1), p.7922906-7922906
Main Authors: Mao, Gang, Li, Cong, Wang, Haiyan, Jv, Yong Hong, Zhang, Yungui, Liu, Lei
Format: Article
Language:English
Subjects:
Adrenergic beta-Antagonists - therapeutic use
Age
Ascites
Biomedical research
Bleeding
Body mass index
Cirrhosis
Creatinine
Esophageal and Gastric Varices - complications
Esophageal and Gastric Varices - drug therapy
Esophagus
Etiology
Female
Flow velocity
Gastrointestinal Hemorrhage - etiology
Health services
Hemodynamics
Hemorrhage
Hemostasis
Hemostatics
Hepatitis
Hepatorenal Syndrome
Humans
Hypertension
Liver
Liver cirrhosis
Liver Cirrhosis - complications
Liver Cirrhosis - drug therapy
Male
Mortality
Parameters
Patients
Propranolol
Propranolol - therapeutic use
Receptors
Regression analysis
Retrospective Studies
Review
Sodium
Somatostatin
Somatostatin - therapeutic use
Ultrasonic imaging
Veins & arteries
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Summary:Esophageal-gastric variceal bleeding occurs in 5–15% of patients with liver cirrhosis annually, and the mortality rate is as high as 20% within 6 weeks of the first bleed. The more compromised the liver function, the higher the mortality. Effective control of bleeding is pivotal for reducing mortality in patients with liver cirrhosis. To explore the effect of nonselective β-receptor blockers (NSBBs) on hemodynamic parameters in liver cirrhosis complicated with esophageal-gastric variceal bleeding and the association with hepatorenal syndrome (HRS), this retrospective study assessed the clinical data of 248 patients with liver cirrhosis and esophageal-gastric variceal hemorrhage admitted to our hospital for research. 112 patients are treated with somatostatin (control group) and 136 with somatostatin+propranolol (study group). The success rate of hemostasis, changes of hemodynamic parameters before and after treatment, and incidence of HRS are compared between the groups. Logistic regression analysis is used to explore the use of propranolol when HRS occurred. NSBBs combined with somatostatin are more effective than somatostatin alone in the treatment of liver cirrhosis complicated with esophageal-gastric variceal bleeding; NSBBs may be associated with the occurrence of HRS.
ISSN:2314-6133
2314-6141
DOI:10.1155/2022/7922906