18F-FDG PET/CT as predictive and prognostic factor in esophageal cancer treated with combined modality treatment

Purpose [18F] fluorodeoxyglucose positron emission tomography/computed tomography ([18F] FDG-PET/CT) is used for diagnosis, staging, response assessment and prognosis prediction in different tumors, but its role in esophageal cancer is still debated. The aim of this study was to evaluate the role of...

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Bibliographic Details
Published in:Annals of nuclear medicine 2022-05, Vol.36 (5), p.450-459
Main Authors: Krengli, Marco, Ferrara, Eleonora, Guaschino, Riccardo, Puta, Erinda, Turri, Lucia, Luciani, Ilaria, Sacchetti, Gian Mauro, Franco, Pierfrancesco, Brambilla, Marco
Format: Article
Language:English
Subjects:
Cancer
Carcinoma, Squamous Cell
Chemoradiotherapy
Chemotherapy
Computed tomography
Esophageal cancer
Esophageal carcinoma
Esophageal Neoplasms - diagnostic imaging
Esophageal Neoplasms - therapy
Esophagus
Evaluation
Fluorine isotopes
Fluorodeoxyglucose F18
Glycolysis
Humans
Imaging
Medical prognosis
Medicine
Medicine & Public Health
Nuclear Medicine
Original
Original Article
Parameters
Patients
Positron emission
Positron emission tomography
Positron Emission Tomography Computed Tomography
Pretreatment
Prognosis
Radiology
Radiopharmaceuticals
Retrospective Studies
Squamous cell carcinoma
Surgery
Survival
Tomography
Tumor Burden
Tumors
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Summary:Purpose [18F] fluorodeoxyglucose positron emission tomography/computed tomography ([18F] FDG-PET/CT) is used for diagnosis, staging, response assessment and prognosis prediction in different tumors, but its role in esophageal cancer is still debated. The aim of this study was to evaluate the role of semiquantitative baseline PET parameters as possible prognostic and predictive factors in a series of esophageal carcinomas treated with combined modalities. Methods 43 patients with esophageal carcinoma were treated with chemoradiotherapy (CRT) followed by surgery in 20 cases and underwent pre-treatment 18F-FDG-PET/CT. Semiquantitative PET parameters were evaluated including Standardized Uptake Value (SUVmax e SUVmean), Metabolic Tumor Volume (MTV) and Total Lesion Glycolysis (TLG) with isocontour of 41 and 50%. Further variables analyzed were gender, primary tumor site, histological type, use of surgery, achievement of a radical resection and the type of chemotherapy regimen. The correlation of all variables with treatment response, loco-regional control (LR), Overall survival (OS) and Disease-Free Survival (DFS) was evaluated. Results SUVmax, SUVmean50 and SUVmean41 were significantly higher in node-positive cases and in squamous cell carcinomas. With respect to prognostic factors, MTV was found to be correlated with OS: patients with MTV41 
ISSN:0914-7187
1864-6433
DOI:10.1007/s12149-022-01733-9