Prognostic Relevance of ZNF844 and Chr 19p13.2 KRAB-Zinc Finger Proteins in Clear Cell Renal Carcinoma

Background/Aim: Clear-cell renal cell carcinoma (ccRCC) is the most common and aggressive form of all urological cancers, with poor prognosis and high mortality. Despite growing evidence of involvement in carcinogenesis, the role of KRAB-ZFP in ccRCC has not been fully explored. KRAB Zinc finger pro...

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Bibliographic Details
Published in:Cancer genomics & proteomics 2022-05, Vol.19 (3), p.305-327
Main Authors: HEYLIGER, SIMONE O., SOLIMAN, KARAM F.A., SAULSBURY, MARILYN D., REAMS, R. RENEE
Format: Article
Language:English
Subjects:
Bioinformatics
Biomarkers
Cancer
Carcinogenesis
Carcinogens
CD4 antigen
Chromosome 19
Clear cell-type renal cell carcinoma
Gene set enrichment analysis
Genomes
Kidney cancer
Lymphocytes T
Medical prognosis
Metastases
Phenotypes
Proteins
Tumor suppressor genes
Tumors
Zinc
Zinc finger proteins
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Summary:Background/Aim: Clear-cell renal cell carcinoma (ccRCC) is the most common and aggressive form of all urological cancers, with poor prognosis and high mortality. Despite growing evidence of involvement in carcinogenesis, the role of KRAB-ZFP in ccRCC has not been fully explored. KRAB Zinc finger proteins (KRAB-ZFPs) are the largest family of mammalian transcription regulators. They are differentially expressed in various tissues during cellular development and phenotypic differentiation. Materials and Methods: In this study, the levels of transcripts of ccRCC from The Cancer Genome Atlas (TCGA) dataset were used to identify prognostic biomarkers in this disease. Results: Using bioinformatics techniques, we demonstrate that approximately 60% of KRAB zinc finger proteins located on chromosome 19p13.2 are differentially expressed, with all but two being down-regulated in ccRCC. Moreover, ZNF844, a paralog of ZNF433, was the most down-regulated across all histological grades and pathological stages (p
ISSN:1109-6535
1790-6245
DOI:10.21873/cgp.20322