[1N,12N]Bis(Ethyl)-cis-6,7-Dehydrospermine: a New Drug for Treatment and Prevention of Cryptosporidium parvum Infection of Mice Deficient in T-Cell Receptor Alpha

Cryptosporidium parvum infection of T-cell receptor alpha (TCR-α)-deficient mice results in a persistent infection. In this study, treatment with a polyamine analogue (SL-11047) prevented C. parvum infection in suckling TCR-α-deficient mice and cleared an existing infection in older mice. Treatment...

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Bibliographic Details
Published in:Antimicrobial Agents and Chemotherapy 2000-10, Vol.44 (10), p.2891-2894
Main Authors: Waters, W.R, Frydman, B, Marton, L.J, Valasinas, A, Reddy, V.K, Harp, J.A, Wannemuehler, M.J, Yarlett, N
Format: Article
Language:English
Subjects:
(N,N)bis(ethyl)-6,7-dehydrospermine
[@u1N,@@u12@N]bis(ethyl)-cis-6,7-dehydrospermine
acute course
animal disease models
animal health
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiparasitic agents
Antiprotozoal Agents
Antiprotozoal Agents - therapeutic use
biochemical pathways
Biological and medical sciences
bis(ethyl)-cis-dehydrospermine
cecum
Cecum - parasitology
Cecum - pathology
chronic diseases
Cryptosporidiosis
Cryptosporidiosis - drug therapy
Cryptosporidiosis - parasitology
Cryptosporidiosis - prevention & control
Cryptosporidium parvum
dehydrospermine
diarrhea
disease control
disease prevention
drug therapy
Experimental Therapeutics
Genes, T-Cell Receptor alpha
Genes, T-Cell Receptor alpha - genetics
histopathology
human health
immunosuppression (physiological)
Medical sciences
Mice
Mice, Inbred C57BL
Mice, Knockout
new drugs
oral administration
persistent infections
Pharmacology. Drug treatments
protozoal infections
putrescine
Putrescine - pharmacology
SL-11047
Spermine
Spermine - analogs & derivatives
Spermine - therapeutic use
T-cell receptor alpha-chain
T-lymphocytes
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Items that cite this one
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Description
Summary:Cryptosporidium parvum infection of T-cell receptor alpha (TCR-α)-deficient mice results in a persistent infection. In this study, treatment with a polyamine analogue (SL-11047) prevented C. parvum infection in suckling TCR-α-deficient mice and cleared an existing infection in older mice. Treatment with putrescine, while capable of preventing infection, did not clear C. parvum from previously infected mice. These findings provide further evidence that polyamine metabolic pathways are targets for new anticryptosporidial chemotherapeutic agents.
ISSN:1098-6596
0066-4804
1098-6596
DOI:10.1128/AAC.44.10.2891-2894.2000