[1N,12N]Bis(Ethyl)-cis-6,7-Dehydrospermine: a New Drug for Treatment and Prevention of Cryptosporidium parvum Infection of Mice Deficient in T-Cell Receptor Alpha

Cryptosporidium parvum infection of T-cell receptor alpha (TCR-α)-deficient mice results in a persistent infection. In this study, treatment with a polyamine analogue (SL-11047) prevented C. parvum infection in suckling TCR-α-deficient mice and cleared an existing infection in older mice. Treatment...

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Published in:Antimicrobial Agents and Chemotherapy 2000-10, Vol.44 (10), p.2891-2894
Main Authors: Waters, W.R, Frydman, B, Marton, L.J, Valasinas, A, Reddy, V.K, Harp, J.A, Wannemuehler, M.J, Yarlett, N
Format: Article
Language:English
Subjects:
(N,N)bis(ethyl)-6,7-dehydrospermine
[@u1N,@@u12@N]bis(ethyl)-cis-6,7-dehydrospermine
acute course
animal disease models
animal health
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiparasitic agents
Antiprotozoal Agents
Antiprotozoal Agents - therapeutic use
biochemical pathways
Biological and medical sciences
bis(ethyl)-cis-dehydrospermine
cecum
Cecum - parasitology
Cecum - pathology
chronic diseases
Cryptosporidiosis
Cryptosporidiosis - drug therapy
Cryptosporidiosis - parasitology
Cryptosporidiosis - prevention & control
Cryptosporidium parvum
dehydrospermine
diarrhea
disease control
disease prevention
drug therapy
Experimental Therapeutics
Genes, T-Cell Receptor alpha
Genes, T-Cell Receptor alpha - genetics
histopathology
human health
immunosuppression (physiological)
Medical sciences
Mice
Mice, Inbred C57BL
Mice, Knockout
new drugs
oral administration
persistent infections
Pharmacology. Drug treatments
protozoal infections
putrescine
Putrescine - pharmacology
SL-11047
Spermine
Spermine - analogs & derivatives
Spermine - therapeutic use
T-cell receptor alpha-chain
T-lymphocytes
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cited_by cdi_FETCH-LOGICAL-a521t-9a5a22653f3ad0c8ec395df0b1985689b776917d654d5e57a46c9117698b4a593
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container_end_page 2894
container_issue 10
container_start_page 2891
container_title Antimicrobial Agents and Chemotherapy
container_volume 44
creator Waters, W.R
Frydman, B
Marton, L.J
Valasinas, A
Reddy, V.K
Harp, J.A
Wannemuehler, M.J
Yarlett, N
description Cryptosporidium parvum infection of T-cell receptor alpha (TCR-α)-deficient mice results in a persistent infection. In this study, treatment with a polyamine analogue (SL-11047) prevented C. parvum infection in suckling TCR-α-deficient mice and cleared an existing infection in older mice. Treatment with putrescine, while capable of preventing infection, did not clear C. parvum from previously infected mice. These findings provide further evidence that polyamine metabolic pathways are targets for new anticryptosporidial chemotherapeutic agents.
doi_str_mv 10.1128/AAC.44.10.2891-2894.2000
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Antiinfectious agents. Antiparasitic agents ; Antiparasitic agents ; Antiprotozoal Agents ; Antiprotozoal Agents - therapeutic use ; biochemical pathways ; Biological and medical sciences ; bis(ethyl)-cis-dehydrospermine ; cecum ; Cecum - parasitology ; Cecum - pathology ; chronic diseases ; Cryptosporidiosis ; Cryptosporidiosis - drug therapy ; Cryptosporidiosis - parasitology ; Cryptosporidiosis - prevention &amp; control ; Cryptosporidium parvum ; dehydrospermine ; diarrhea ; disease control ; disease prevention ; drug therapy ; Experimental Therapeutics ; Genes, T-Cell Receptor alpha ; Genes, T-Cell Receptor alpha - genetics ; histopathology ; human health ; immunosuppression (physiological) ; Medical sciences ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; new drugs ; oral administration ; persistent infections ; Pharmacology. 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Antiinfectious agents. Antiparasitic agents</topic><topic>Antiparasitic agents</topic><topic>Antiprotozoal Agents</topic><topic>Antiprotozoal Agents - therapeutic use</topic><topic>biochemical pathways</topic><topic>Biological and medical sciences</topic><topic>bis(ethyl)-cis-dehydrospermine</topic><topic>cecum</topic><topic>Cecum - parasitology</topic><topic>Cecum - pathology</topic><topic>chronic diseases</topic><topic>Cryptosporidiosis</topic><topic>Cryptosporidiosis - drug therapy</topic><topic>Cryptosporidiosis - parasitology</topic><topic>Cryptosporidiosis - prevention &amp; control</topic><topic>Cryptosporidium parvum</topic><topic>dehydrospermine</topic><topic>diarrhea</topic><topic>disease control</topic><topic>disease prevention</topic><topic>drug therapy</topic><topic>Experimental Therapeutics</topic><topic>Genes, T-Cell Receptor alpha</topic><topic>Genes, T-Cell Receptor alpha - genetics</topic><topic>histopathology</topic><topic>human health</topic><topic>immunosuppression (physiological)</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>new drugs</topic><topic>oral administration</topic><topic>persistent infections</topic><topic>Pharmacology. 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Agents Chemother</stitle><addtitle>Antimicrob Agents Chemother</addtitle><date>2000-10-01</date><risdate>2000</risdate><volume>44</volume><issue>10</issue><spage>2891</spage><epage>2894</epage><pages>2891-2894</pages><issn>1098-6596</issn><issn>0066-4804</issn><eissn>1098-6596</eissn><coden>AACHAX</coden><abstract>Cryptosporidium parvum infection of T-cell receptor alpha (TCR-α)-deficient mice results in a persistent infection. In this study, treatment with a polyamine analogue (SL-11047) prevented C. parvum infection in suckling TCR-α-deficient mice and cleared an existing infection in older mice. Treatment with putrescine, while capable of preventing infection, did not clear C. parvum from previously infected mice. These findings provide further evidence that polyamine metabolic pathways are targets for new anticryptosporidial chemotherapeutic agents.</abstract><cop>Washington, DC</cop><pub>American Society for Microbiology</pub><pmid>10991882</pmid><doi>10.1128/AAC.44.10.2891-2894.2000</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record>
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identifier ISSN: 1098-6596
ispartof Antimicrobial Agents and Chemotherapy, 2000-10, Vol.44 (10), p.2891-2894
issn 1098-6596
0066-4804
1098-6596
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_90173
source American Society for Microbiology Journals; PubMed Central
subjects (N,N)bis(ethyl)-6,7-dehydrospermine
[@u1N,@@u12@N]bis(ethyl)-cis-6,7-dehydrospermine
acute course
animal disease models
animal health
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiparasitic agents
Antiprotozoal Agents
Antiprotozoal Agents - therapeutic use
biochemical pathways
Biological and medical sciences
bis(ethyl)-cis-dehydrospermine
cecum
Cecum - parasitology
Cecum - pathology
chronic diseases
Cryptosporidiosis
Cryptosporidiosis - drug therapy
Cryptosporidiosis - parasitology
Cryptosporidiosis - prevention & control
Cryptosporidium parvum
dehydrospermine
diarrhea
disease control
disease prevention
drug therapy
Experimental Therapeutics
Genes, T-Cell Receptor alpha
Genes, T-Cell Receptor alpha - genetics
histopathology
human health
immunosuppression (physiological)
Medical sciences
Mice
Mice, Inbred C57BL
Mice, Knockout
new drugs
oral administration
persistent infections
Pharmacology. Drug treatments
protozoal infections
putrescine
Putrescine - pharmacology
SL-11047
Spermine
Spermine - analogs & derivatives
Spermine - therapeutic use
T-cell receptor alpha-chain
T-lymphocytes
title [1N,12N]Bis(Ethyl)-cis-6,7-Dehydrospermine: a New Drug for Treatment and Prevention of Cryptosporidium parvum Infection of Mice Deficient in T-Cell Receptor Alpha
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