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Randomized Controlled Trial of a Cognitive Intervention to Improve Memory in Heart Failure
•Randomized, controlled interventional trial in 256 patients with heart failure.•Measures: memory, working memory, instrumental activities of living, quality of life.•All treatment groups had significant improvements of cognitive measures over 8 months.•Computerized cognitive training did not signif...
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| Published in: | Journal of cardiac failure 2022-04, Vol.28 (4), p.519-530 |
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| container_title | Journal of cardiac failure |
| container_volume | 28 |
| creator | Pressler, Susan J. Jung, Miyeon Gradus-Pizlo, Irmina Titler, Marita G. Smith, Dean G. Gao, Sujuan Lake, Kittie Reid Burney, Heather Clark, David G. Wierenga, Kelly L. Dorsey, Susan G. Giordani, Bruno |
| description | •Randomized, controlled interventional trial in 256 patients with heart failure.•Measures: memory, working memory, instrumental activities of living, quality of life.•All treatment groups had significant improvements of cognitive measures over 8 months.•Computerized cognitive training did not significantly alter outcomes over controls.•Nurse enhancement and decreases in serum brain-derived neurotrophic factor were found.
The objective of this 3-arm randomized controlled trial was to evaluate the efficacy of computerized cognitive training (CCT) in improving primary outcomes of delayed-recall memory and serum brain-derived neurotrophic factor (BDNF) levels; and the secondary outcomes were working memory, instrumental activities of daily living (IADLs) and health-related quality of life (HRQL) in patients with heart failure (HF).
Patients (n = 256) were randomly assigned to 8 weeks of CCT using BrainHQ, computerized crossword puzzles active control intervention, and usual care. All patients received weekly nurse-enhancement interventions. Data were collected at enrollment and baseline visits and at 10 weeks and 4 and 8 months. In mixed effects models, there were no statistically significant group or group-by-time differences in outcomes. There were statistically significant differences over time in all outcomes in all groups. Patients improved over time on measures of delayed-recall memory, working memory, IADLs, and HRQL and had decreased serum BDNF.
CCT did not improve outcomes compared with the active control intervention and usual care. Nurse-enhancement interventions may have led to improved outcomes over time. Future studies are needed to test nurse-enhancement interventions in combination with other cognitive interventions to improve memory in persons with HF.
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| doi_str_mv | 10.1016/j.cardfail.2021.10.008 |
| format | article |
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The objective of this 3-arm randomized controlled trial was to evaluate the efficacy of computerized cognitive training (CCT) in improving primary outcomes of delayed-recall memory and serum brain-derived neurotrophic factor (BDNF) levels; and the secondary outcomes were working memory, instrumental activities of daily living (IADLs) and health-related quality of life (HRQL) in patients with heart failure (HF).
Patients (n = 256) were randomly assigned to 8 weeks of CCT using BrainHQ, computerized crossword puzzles active control intervention, and usual care. All patients received weekly nurse-enhancement interventions. Data were collected at enrollment and baseline visits and at 10 weeks and 4 and 8 months. In mixed effects models, there were no statistically significant group or group-by-time differences in outcomes. There were statistically significant differences over time in all outcomes in all groups. Patients improved over time on measures of delayed-recall memory, working memory, IADLs, and HRQL and had decreased serum BDNF.
CCT did not improve outcomes compared with the active control intervention and usual care. Nurse-enhancement interventions may have led to improved outcomes over time. Future studies are needed to test nurse-enhancement interventions in combination with other cognitive interventions to improve memory in persons with HF.
[Display omitted]</description><identifier>ISSN: 1071-9164</identifier><identifier>ISSN: 1532-8414</identifier><identifier>EISSN: 1532-8414</identifier><identifier>DOI: 10.1016/j.cardfail.2021.10.008</identifier><identifier>PMID: 34763080</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Activities of Daily Living ; Brain-Derived Neurotrophic Factor ; Cognition ; cognitive dysfunction ; computerized cognitive training ; heart failure ; Heart Failure - complications ; Heart Failure - therapy ; Humans ; nurse-enhancement intervention ; Quality of Life</subject><ispartof>Journal of cardiac failure, 2022-04, Vol.28 (4), p.519-530</ispartof><rights>2021 Elsevier Inc.</rights><rights>Copyright © 2021 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-63a6d6a88a637eeb232efc48881b27b37d4296e138ffa97dbd520a77fa12bf6f3</citedby><cites>FETCH-LOGICAL-c471t-63a6d6a88a637eeb232efc48881b27b37d4296e138ffa97dbd520a77fa12bf6f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34763080$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pressler, Susan J.</creatorcontrib><creatorcontrib>Jung, Miyeon</creatorcontrib><creatorcontrib>Gradus-Pizlo, Irmina</creatorcontrib><creatorcontrib>Titler, Marita G.</creatorcontrib><creatorcontrib>Smith, Dean G.</creatorcontrib><creatorcontrib>Gao, Sujuan</creatorcontrib><creatorcontrib>Lake, Kittie Reid</creatorcontrib><creatorcontrib>Burney, Heather</creatorcontrib><creatorcontrib>Clark, David G.</creatorcontrib><creatorcontrib>Wierenga, Kelly L.</creatorcontrib><creatorcontrib>Dorsey, Susan G.</creatorcontrib><creatorcontrib>Giordani, Bruno</creatorcontrib><title>Randomized Controlled Trial of a Cognitive Intervention to Improve Memory in Heart Failure</title><title>Journal of cardiac failure</title><addtitle>J Card Fail</addtitle><description>•Randomized, controlled interventional trial in 256 patients with heart failure.•Measures: memory, working memory, instrumental activities of living, quality of life.•All treatment groups had significant improvements of cognitive measures over 8 months.•Computerized cognitive training did not significantly alter outcomes over controls.•Nurse enhancement and decreases in serum brain-derived neurotrophic factor were found.
The objective of this 3-arm randomized controlled trial was to evaluate the efficacy of computerized cognitive training (CCT) in improving primary outcomes of delayed-recall memory and serum brain-derived neurotrophic factor (BDNF) levels; and the secondary outcomes were working memory, instrumental activities of daily living (IADLs) and health-related quality of life (HRQL) in patients with heart failure (HF).
Patients (n = 256) were randomly assigned to 8 weeks of CCT using BrainHQ, computerized crossword puzzles active control intervention, and usual care. All patients received weekly nurse-enhancement interventions. Data were collected at enrollment and baseline visits and at 10 weeks and 4 and 8 months. In mixed effects models, there were no statistically significant group or group-by-time differences in outcomes. There were statistically significant differences over time in all outcomes in all groups. Patients improved over time on measures of delayed-recall memory, working memory, IADLs, and HRQL and had decreased serum BDNF.
CCT did not improve outcomes compared with the active control intervention and usual care. Nurse-enhancement interventions may have led to improved outcomes over time. Future studies are needed to test nurse-enhancement interventions in combination with other cognitive interventions to improve memory in persons with HF.
[Display omitted]</description><subject>Activities of Daily Living</subject><subject>Brain-Derived Neurotrophic Factor</subject><subject>Cognition</subject><subject>cognitive dysfunction</subject><subject>computerized cognitive training</subject><subject>heart failure</subject><subject>Heart Failure - complications</subject><subject>Heart Failure - therapy</subject><subject>Humans</subject><subject>nurse-enhancement intervention</subject><subject>Quality of Life</subject><issn>1071-9164</issn><issn>1532-8414</issn><issn>1532-8414</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNqFUU1vEzEQtRCIlsJfqHzkssFfsb0XBIpoG6kICbWXXiyvPS6Odu1gbyKVX19HaSs4cZrRmzdvnuYhdE7JghIqP20WzhYfbBwXjDDawAUh-hU6pUvOOi2oeN16omjXUylO0LtaN6QxBFFv0QkXSnKiySm6-2mTz1P8Ax6vcppLHsfW3pRoR5wDtg29T3GOe8DrNEPZQ5pjTnjOeD1tS274d5hyecAx4SuwZcYXzdWuwHv0JtixwoeneoZuL77drK666x-X69XX684JRedOciu9tFpbyRXAwDiD4ITWmg5MDVx5wXoJlOsQbK_84JeMWKWCpWwIMvAz9Pmou90NE3jXDBY7mm2Jky0PJtto_p2k-Mvc573pCdWip03g45NAyb93UGczxepgHG2CvKuGLXsles0ZaVR5pLqSay0QXs5QYg7BmI15DsYcgjng7e1t8fxvky9rz0k0wpcjAdqr9hGKqS5CcuBjATcbn-P_bjwC0HikbQ</recordid><startdate>20220401</startdate><enddate>20220401</enddate><creator>Pressler, Susan J.</creator><creator>Jung, Miyeon</creator><creator>Gradus-Pizlo, Irmina</creator><creator>Titler, Marita G.</creator><creator>Smith, Dean G.</creator><creator>Gao, Sujuan</creator><creator>Lake, Kittie Reid</creator><creator>Burney, Heather</creator><creator>Clark, David G.</creator><creator>Wierenga, Kelly L.</creator><creator>Dorsey, Susan G.</creator><creator>Giordani, Bruno</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20220401</creationdate><title>Randomized Controlled Trial of a Cognitive Intervention to Improve Memory in Heart Failure</title><author>Pressler, Susan J. ; Jung, Miyeon ; Gradus-Pizlo, Irmina ; Titler, Marita G. ; Smith, Dean G. ; Gao, Sujuan ; Lake, Kittie Reid ; Burney, Heather ; Clark, David G. ; Wierenga, Kelly L. ; Dorsey, Susan G. ; Giordani, Bruno</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-63a6d6a88a637eeb232efc48881b27b37d4296e138ffa97dbd520a77fa12bf6f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Activities of Daily Living</topic><topic>Brain-Derived Neurotrophic Factor</topic><topic>Cognition</topic><topic>cognitive dysfunction</topic><topic>computerized cognitive training</topic><topic>heart failure</topic><topic>Heart Failure - complications</topic><topic>Heart Failure - therapy</topic><topic>Humans</topic><topic>nurse-enhancement intervention</topic><topic>Quality of Life</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pressler, Susan J.</creatorcontrib><creatorcontrib>Jung, Miyeon</creatorcontrib><creatorcontrib>Gradus-Pizlo, Irmina</creatorcontrib><creatorcontrib>Titler, Marita G.</creatorcontrib><creatorcontrib>Smith, Dean G.</creatorcontrib><creatorcontrib>Gao, Sujuan</creatorcontrib><creatorcontrib>Lake, Kittie Reid</creatorcontrib><creatorcontrib>Burney, Heather</creatorcontrib><creatorcontrib>Clark, David G.</creatorcontrib><creatorcontrib>Wierenga, Kelly L.</creatorcontrib><creatorcontrib>Dorsey, Susan G.</creatorcontrib><creatorcontrib>Giordani, Bruno</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of cardiac failure</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pressler, Susan J.</au><au>Jung, Miyeon</au><au>Gradus-Pizlo, Irmina</au><au>Titler, Marita G.</au><au>Smith, Dean G.</au><au>Gao, Sujuan</au><au>Lake, Kittie Reid</au><au>Burney, Heather</au><au>Clark, David G.</au><au>Wierenga, Kelly L.</au><au>Dorsey, Susan G.</au><au>Giordani, Bruno</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Randomized Controlled Trial of a Cognitive Intervention to Improve Memory in Heart Failure</atitle><jtitle>Journal of cardiac failure</jtitle><addtitle>J Card Fail</addtitle><date>2022-04-01</date><risdate>2022</risdate><volume>28</volume><issue>4</issue><spage>519</spage><epage>530</epage><pages>519-530</pages><issn>1071-9164</issn><issn>1532-8414</issn><eissn>1532-8414</eissn><abstract>•Randomized, controlled interventional trial in 256 patients with heart failure.•Measures: memory, working memory, instrumental activities of living, quality of life.•All treatment groups had significant improvements of cognitive measures over 8 months.•Computerized cognitive training did not significantly alter outcomes over controls.•Nurse enhancement and decreases in serum brain-derived neurotrophic factor were found.
The objective of this 3-arm randomized controlled trial was to evaluate the efficacy of computerized cognitive training (CCT) in improving primary outcomes of delayed-recall memory and serum brain-derived neurotrophic factor (BDNF) levels; and the secondary outcomes were working memory, instrumental activities of daily living (IADLs) and health-related quality of life (HRQL) in patients with heart failure (HF).
Patients (n = 256) were randomly assigned to 8 weeks of CCT using BrainHQ, computerized crossword puzzles active control intervention, and usual care. All patients received weekly nurse-enhancement interventions. Data were collected at enrollment and baseline visits and at 10 weeks and 4 and 8 months. In mixed effects models, there were no statistically significant group or group-by-time differences in outcomes. There were statistically significant differences over time in all outcomes in all groups. Patients improved over time on measures of delayed-recall memory, working memory, IADLs, and HRQL and had decreased serum BDNF.
CCT did not improve outcomes compared with the active control intervention and usual care. Nurse-enhancement interventions may have led to improved outcomes over time. Future studies are needed to test nurse-enhancement interventions in combination with other cognitive interventions to improve memory in persons with HF.
[Display omitted]</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>34763080</pmid><doi>10.1016/j.cardfail.2021.10.008</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of cardiac failure, 2022-04, Vol.28 (4), p.519-530 |
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| language | eng |
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| source | ScienceDirect Freedom Collection |
| subjects | Activities of Daily Living Brain-Derived Neurotrophic Factor Cognition cognitive dysfunction computerized cognitive training heart failure Heart Failure - complications Heart Failure - therapy Humans nurse-enhancement intervention Quality of Life |
| title | Randomized Controlled Trial of a Cognitive Intervention to Improve Memory in Heart Failure |
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