Prevalence and genetic characterization of noroviruses in children with acute gastroenteritis in Senegal, 2007–2010

Norovirus is the leading cause of sporadic and epidemic acute gastroenteritis (AGE) in children and adults around the world. We investigated the molecular diversity of noroviruses in a pediatric population in Senegal between 2007 and 2010 before the rotavirus vaccine implementation. Stool samples we...

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Bibliographic Details
Published in:Journal of medical virology 2022-06, Vol.94 (6), p.2640-2644
Main Authors: Kebe, Ousmane, Fernandez‐Garcia, Maria‐Dolores, Zinsou, Boris‐Enock, Diop, Amadou, Fall, Amary, Ndiaye, Ndack, Vinjé, Jan, Ndiaye, Kader
Format: Article
Language:English
Subjects:
Adult
Age
Caliciviridae Infections - epidemiology
Child
Child, Preschool
Children
diarrhea
Epidemics
Feces
Gastroenteritis
Gastroenteritis - epidemiology
Genetic Variation
Genotype
genotype diversity
Genotypes
GII.4
GII.6
Humans
Infant
Norovirus
Norovirus - genetics
Pediatrics
Phylogeny
Polymerase chain reaction
Prevalence
Reaction products
Reverse transcription
Rotavirus
Senegal
Senegal - epidemiology
Vaccines
Virology
Viruses
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Summary:Norovirus is the leading cause of sporadic and epidemic acute gastroenteritis (AGE) in children and adults around the world. We investigated the molecular diversity of noroviruses in a pediatric population in Senegal between 2007 and 2010 before the rotavirus vaccine implementation. Stool samples were collected from 599 children under 5 years of age consulting for AGE in a hospital in Dakar. Specimens were screened for noroviruses using the Allplex™ GI‐Virus Assay. Positive samples were genotyped after sequencing of conventional reverse transcription‐polymerase chain reaction products. Noroviruses were detected in 79 (13.2%) of the children, with GII.4 (64%) and GII.6 (10%) as the most frequently identified genotypes. Our study describes the distribution of genotypes between 2007 and 2010 and should be a baseline for comparison with more contemporary studies. This could help decision‐makers on possible choices of norovirus vaccines in the event of future introduction.
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.27496