Efficacy and Safety of Xiaoyao Recipe in the Treatment of Poststroke Depression: A Systematic Review and Meta-Analysis

Background. Poststroke depression (PSD) is a common neuropsychiatric disorder that affects the disability, mortality, functional recovery, and quality of daily life of patients. Xiaoyao Recipe (XYR) is often used to treat PSD and has achieved good clinical effects, but it lacks reliable evidence. Ob...

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Published in:Evidence-based complementary and alternative medicine 2022, Vol.2022, p.4385783-10
Main Authors: Wang, Dou, Li, Tao, Ron, Jie, Mao, Meiling, Yang, Yifan, Feng, Yalun, Yan, Yongmei
Format: Article
Language:English
Subjects:
Activities of daily living
Antidepressants
Bias
Clinical trials
Health care policy
Medical research
Mental depression
Mental disorders
Meta-analysis
Patients
Recovery of function
Review
Serotonin
Stroke
Systematic review
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Summary:Background. Poststroke depression (PSD) is a common neuropsychiatric disorder that affects the disability, mortality, functional recovery, and quality of daily life of patients. Xiaoyao Recipe (XYR) is often used to treat PSD and has achieved good clinical effects, but it lacks reliable evidence. Objective. This study aims to evaluate the effectiveness and safety of XYR on PSD through meta-analysis. Methods. A comprehensive literature search was carried out in multiple databases, including PubMed, the Cochrane Library, Chinese Biomedical Literature Service System, China National Knowledge Infrastructure, Wanfang Database, VIP Database, and ClinicalTrials, from inception to July 1, 2021, to collect randomized controlled trials that applied XYR for patients with PSD. For a controlled trial, the search time limit was set from the time of the database’s establishment to July 2021. Two experienced researchers independently screened the literature according to the inclusion and exclusion criteria, extracted data, evaluated the quality of the literature, and used RevMan 5.3 software for meta-analysis. Results. A total of 12 studies were included in this study, involving 882 patients with PSD who were hospitalized or outpatients. The meta-analysis results showed that the total effective rate (p
ISSN:1741-427X
1741-4288
DOI:10.1155/2022/4385783