Linezolid therapy of Staphylococcus aureus experimental osteomyelitis

The in vivo activity of linezolid or cefazolin against a clinical isolate of methicillin-susceptible Staphylococcus aureus (linezolid MIC, 2 microg/ml) was studied in a rat model of experimental osteomyelitis. Sixty rats with experimental S. aureus osteomyelitis were treated for 21 days with no anti...

Full description

Saved in:
Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 2000-12, Vol.44 (12), p.3438-3440
Main Authors: PATEL, Robin, PIPER, Kerryl E, ROUSE, Mark S, STECKELBERG, James M
Format: Article
Language:English
Subjects:
Acetamides - blood
Acetamides - therapeutic use
Animals
Anti-Bacterial Agents - blood
Anti-Bacterial Agents - therapeutic use
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
cefazolin
Colony Count, Microbial
Disease Models, Animal
Experimental Therapeutics
Humans
Linezolid
Male
Medical sciences
Osteomyelitis - blood
Osteomyelitis - drug therapy
Oxazolidinones - blood
Oxazolidinones - therapeutic use
Pharmacology. Drug treatments
Rats
Rats, Wistar
Staphylococcal Infections - blood
Staphylococcal Infections - drug therapy
Staphylococcus aureus
Staphylococcus aureus - drug effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The in vivo activity of linezolid or cefazolin against a clinical isolate of methicillin-susceptible Staphylococcus aureus (linezolid MIC, 2 microg/ml) was studied in a rat model of experimental osteomyelitis. Sixty rats with experimental S. aureus osteomyelitis were treated for 21 days with no antimicrobial, with 25 microg of linezolid per kg of body weight administered intraperitoneally twice or three times a day, or with 50 microg of cefazolin per kg administered intramuscularly three times a day. After treatment, the animals were sacrificed and the infected tibiae were processed for quantitative bacterial cultures. The results of treatment were expressed as log(10) CFU/gram of bone and analyzed by rank sum analysis. The results of linezolid treatment were not significantly different from those of untreated controls, while cefazolin treatment was significantly more active than no treatment or linezolid treatment.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.44.12.3438-3440.2000