Correlation between Vaginal Microecological Status and Prognosis of CIN Patients with High-Risk HPV Infection

Many microorganisms live in the vagina of healthy women. They interact with and compete with the microenvironment in the female vagina to form a dynamic balance of the microenvironment in the female vagina. However, imbalanced vaginal microecology can lead to vaginal resistance to pathogenic microor...

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Bibliographic Details
Published in:BioMed research international 2022-04, Vol.2022, p.3620232-11
Main Authors: Zhang, Huizhen, Jin, Shuangling, Ji, Aifang, Zhang, Chunyan, Shi, Shujing
Format: Article
Language:English
Subjects:
Bacteria
Biomedical research
Care and treatment
Cervical cancer
Cervix
Chi-square test
Diagnosis
Disease prevention
Female
Gynecology
Health aspects
Health risks
Human papillomavirus
Humans
Infections
Infectious diseases
Lesions
Life history
Microenvironments
Microorganisms
Morphology
Papillomaviridae
Papillomavirus Infections
Pathogens
Patients
Prevention
Prognosis
Reproductive system
Risk analysis
Risk Factors
Risk management
Sexually transmitted diseases
Statistical analysis
Statistical tests
Tumor Microenvironment
Uterine Cervical Neoplasms
Vagina
Vagina - pathology
Vaginal Smears
Women
Womens health
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Summary:Many microorganisms live in the vagina of healthy women. They interact with and compete with the microenvironment in the female vagina to form a dynamic balance of the microenvironment in the female vagina. However, imbalanced vaginal microecology can lead to vaginal resistance to pathogenic microorganisms. Poor capacity can cause women to develop infections of the reproductive tract. This article analyzes the vaginal microecological status of women with high-risk HPV infection for more than 6 months and healthy women and explores the risk factors that cause long-term high-risk HPV infection for timely detection and regulation of possible vaginal microecological imbalance in women with high-risk HPV infection for more than 6 months to prevent further development of cervical lesions in such patients. This article covers women with a sexual life history who attended the gynecology department of a hospital from January 2020 to September 2021. There were 280 patients in the experimental group: positive high-risk HPV; and there were 140 patients in the control group: negative high-risk HPV test. The correlation between vaginal microecology of CIN patients and patient prognosis according to the subject’s vaginal microecology test results and prognosis of various levels of cervical lesions was analyzed. The experiment proved that the detection rate of normal vaginal microecology in the experimental group was 12.14% (34/280) compared with the detection rate of 29.29% (41/140) in the control group, and there was a trend of decrease, and the difference was statistically significant (χ2=17.23,P
ISSN:2314-6133
2314-6141
DOI:10.1155/2022/3620232