Impact of Surgical Intervention on Nonobstructive Dysphagia: A Retrospective Study Based on High-Resolution Impedance Manometry in a Taiwanese Population at a Single Institution

Esophageal motility disorders account for a large proportion of nonobstructive dysphagia cases, which constitute a heterogeneous group of diagnoses that commonly result in peristaltic derangement and impaired relaxation of the lower esophageal sphincter. We performed a single-institution retrospecti...

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Bibliographic Details
Published in:Journal of personalized medicine 2022-04, Vol.12 (4), p.590
Main Authors: Lin, Gang-Hua, Lin, Kuan-Hsun, Lin, Szu-Yu, Huang, Tsai-Wang, Chang, Hung, Huang, Hsu-Kai
Format: Article
Language:English
Subjects:
Achalasia
Contractility
Dysphagia
Endoscopy
Esophageal sphincter
Esophagus
Intervention
Laparoscopy
Motility
Ostomy
Palliation
Patients
Precision medicine
Sphincter
Statistical analysis
Surgery
Topography
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Summary:Esophageal motility disorders account for a large proportion of nonobstructive dysphagia cases, which constitute a heterogeneous group of diagnoses that commonly result in peristaltic derangement and impaired relaxation of the lower esophageal sphincter. We performed a single-institution retrospective study enrolling consecutive patients with chief complaints of dysphagia who underwent HRIM from December 2014 to December 2019, and analyzed demographic, clinical, and manometric data using descriptive statistics. In total, 277 identified patients were included in the final analysis. Ineffective esophageal motility ( = 152, 24.5%) was the most common diagnosis by HRIM, followed by absent contractility, EGJ outflow obstruction, type II achalasia, and type I achalasia. Furthermore, surgery including exploratory, laparoscopic, and robotic myotomy, as well as POEM, is considered the most effective treatment for patients with non-spastic achalasia and EGJOO, due to its effective symptom palliation and prevention of disease progression; surgery also contributes to an obvious improvement of dysphagia compared with slightly less efficacy for other related symptoms. Our study aimed to elaborate the clinical characteristics of patients with nonobstructive dysphagia based on HRIM in a Taiwanese population, and to analyze the therapeutic outcomes of such patients who ultimately underwent surgical interventions.
ISSN:2075-4426
2075-4426
DOI:10.3390/jpm12040590