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A Novel Selenium Polysaccharide Alleviates the Manganese (Mn)-Induced Toxicity in Hep G2 Cells and Caenorhabditis elegans

Manganese (Mn) is now known to have a variety of toxicities, particularly when exposed to it in the workplace. However, there are still ineffective methods for reducing Mn's hazardous effects. In this study, a new selenium polysaccharide (Se-PCS) was developed from the shell of to reduce Mn tox...

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Published in:International journal of molecular sciences 2022-04, Vol.23 (8), p.4097
Main Authors: Chen, Tao, Wang, Xiaoju, Yan, Xinchen, Dai, Yali, Liang, Tao, Zhou, Lijun, Feng, Shiling, Yuan, Ming, Yang, Hongyu, Ding, Chunbang
Format: Article
Language:English
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Summary:Manganese (Mn) is now known to have a variety of toxicities, particularly when exposed to it in the workplace. However, there are still ineffective methods for reducing Mn's hazardous effects. In this study, a new selenium polysaccharide (Se-PCS) was developed from the shell of to reduce Mn toxicity in vitro and in vivo. The results revealed that Se-PCS may boost cell survival in Hep G2 cells exposed to Mn and activate antioxidant enzyme activity, lowering ROS and cell apoptosis. Furthermore, after being treated with Se-PCS, survived longer under Mn stress. , a tolerant critical gene, was turned on. Moreover, the antioxidant system was enhanced as the increase in strong antioxidant enzyme activity and high expression of the , , and genes. A variety of mutations were also used to confirm that Se-PCS downregulated the insulin signaling pathway. These findings showed that Se-PCS protected Hep G2 cells and via the insulin/IGF-1 signaling pathway and that it could be developed into a promising medication to treat Mn toxicity.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23084097