Inclusion of sire by herd interaction effect in the genomic evaluation for weaning weight of American Angus

• Published in: Journal of animal science 2022-03, Vol.100 (3)
• Main Authors: Jang, Sungbong, Lourenco, Daniela, Miller, Stephen
• Format: Article
• Language: English
• Subjects: Algorithms; Animal Genetics and Genomics; Animals; Artificial insemination; Body Weight - genetics; Breeding; Cattle - genetics; Covariance; Genetic diversity; Genetic variance; Genome; Genomics; Genotypes; Maternal effects; Models, Genetic; Phenotypic variations; Reproduction (biology); United States; Variance; Weaning
• ISSN: 0021-8812; 1525-3163
• DOI: 10.1093/jas/skac057

Abstract A spurious negative genetic correlation between direct and maternal effects of weaning weight (WW) in beef cattle has historically been problematic for researchers and industry. Previous research has suggested the covariance between sires and herds may be contributing to this relationship. The objective of this study was to estimate the variance components (VC) for WW in American Angus with and without sire by herd (S×H) interaction effect when genomic information is used or not. Five subsets of ~100k animals for each subset were used. When genomic information was included, genotypes were added for 15,637 animals. Five replicates were performed. Four different models were tested, namely, M1: without S×H interaction effect and with covariance between direct and maternal effect (σam) ≠ 0; M2: with S×H interaction effect and σam ≠ 0; M3: without S×H interaction effect and with σam = 0; M4: with S×H interaction effect and σam = 0. VC were estimated using the restricted maximum likelihood (REML) and single-step genomic REML (ssGREML) with the average information algorithm. Breeding values were computed using single-step genomic BLUP for the models above and one additional model, which had the covariance zeroed after the estimation of VC (M5). The ability of each model to predict future breeding values was investigated with the linear regression method. Under REML, when the S×H interaction effect was added to the model, both direct and maternal genetic variances were greatly reduced, and the negative covariance became positive (i.e., when moving from M1 to M2). Similar patterns were observed under ssGREML, but with less reduction in the direct and maternal genetic variances and still a negative covariance. Models with the S×H interaction effect (M2 and M4) had a better fit according to the Akaike information criteria. Breeding values from those models were more accurate and had less bias than the other three models. The rankings and breeding values of artificial insemination sires (N = 1,977) greatly changed when the S×H interaction effect was fit in the model. Although the S×H interaction effect accounted for 3% to 5% of the total phenotypic variance and improved the model fit, this change in the evaluation model will cause severe reranking among animals. Lay Summary A spurious negative genetic correlation between direct and maternal effects of weaning weight (WW) in beef cattle has been problematic for researchers and industry. Previous research sugge