Characterizing Intracranial Hemodynamics in Sickle Cell Anemia: Impact of Patient-Specific Viscosity

• Published in: Cardiovascular engineering and technology 2022-02, Vol.13 (1), p.104-119
• Main Authors: Keller, Sara B., Bumpus, Jacob M., Gatenby, J. Christopher, Yang, Elizabeth, Kassim, Adetola A., Dampier, Carlton, Gore, John C., Buck, Amanda K. W.
• Format: Article
• Language: English
• Subjects: Adult; Anemia; Anemia, Sickle Cell - diagnosis; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedical Engineering/Biotechnology; Biomedicine; Blood vessels; Cardiology; Child; Errors; Flow velocity; Hemodynamics; Hemodynamics - physiology; Humans; Models, Cardiovascular; Occlusion; Original Article; Parameters; Patients; Shear rate; Shear Strength; Sickle cell anemia; Simulation; Stress, Mechanical; Stroke; Viscosity; Wall flow; Wall shear stresses
• ISSN: 1869-408X; 1869-4098
• DOI: 10.1007/s13239-021-00559-2

Purpose Pediatric and adult patients with sickle cell anemia (SCA) are at increased risk of stroke and cerebrovascular accident. In the general adult population, there is a relationship between arterial hemodynamics and pathology; however, this relationship in SCA patients remains to be elucidated. The aim of this work was to characterize circle of Willis hemodynamics in patients with SCA and quantify the impact of viscosity choice on pathophysiologically-relevant hemodynamics measures. Methods Based on measured vascular geometries, time-varying flow rates, and blood parameters, detailed patient-specific simulations of the circle of Willis were conducted for SCA patients ( n  = 6). Simulations quantified the impact of patient-specific and standard blood viscosities on wall shear stress (WSS). Results These results demonstrated that use of a standard blood viscosity introduces large errors into the estimation of pathophysiologically-relevant hemodynamic parameters. Standard viscosity models overpredicted peak WSS by 55% and 49% for steady and pulsatile flow, respectively. Moreover, these results demonstrated non-uniform, spatial patterns of positive and negative WSS errors related to viscosity, and standard viscosity simulations overpredicted the time-averaged WSS by 32% (standard deviation = 7.1%). Finally, differences in shear rate demonstrated that the viscosity choice alters the simulated near-wall flow field, impacting hemodynamics measures. Conclusions This work presents simulations of circle of Willis arterial flow in SCA patients and demonstrates the importance and feasibility of using a patient-specific viscosity in these simulations. Accurately characterizing cerebrovascular hemodynamics in SCA populations has potential for elucidating the pathophysiology of large-vessel occlusion, aneurysms, and tissue damage in these patients.