High expression of protein tyrosine kinase 7 in oral squamous cell carcinoma: Clinicopathological correlation and prognosis relevance

Background The purpose of this study was to evaluate the association between the　immunohistochemistry (IHC) of protein tyrosine kinase 7 (PTK7) expression and clinicopathological factors of oral squamous cell carcinoma (OSCC). Methods Tissue specimens were obtained from 80 patients with primary OSCC...

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Published in:Clinical and experimental dental research 2022-04, Vol.8 (2), p.506-512
Main Authors: Kimura, Yujiro, Yoshizawa, Kunio, Hotta‐Osada, Asami, Moroi, Akinori, Ishii, Hiroki, Sakurai, Daiju, Saitoh, Masao, Oishi, Naoki, Kondo, Tetsuo, Ueki, Koichiro
Format: Article
Language:English
Subjects:
Antibodies
Biomarkers
Biopsy
Cancer therapies
Cell Adhesion Molecules - genetics
Cholangiocarcinoma
Classification
Humans
invasion
Kinases
Medical prognosis
Metastasis
Mouth Neoplasms - pathology
Oral cancer
oral squamous cell carcinoma
Original
Prognosis
protein tyrosine kinase 7
Protein-Tyrosine Kinases
Receptor Protein-Tyrosine Kinases - genetics
Squamous cell carcinoma
Squamous Cell Carcinoma of Head and Neck - pathology
Survival analysis
Tumors
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Summary:Background The purpose of this study was to evaluate the association between the　immunohistochemistry (IHC) of protein tyrosine kinase 7 (PTK7) expression and clinicopathological factors of oral squamous cell carcinoma (OSCC). Methods Tissue specimens were obtained from 80 patients with primary OSCC. IHC scoring was conducted according to the rate of positive cell and staining intensity. We used the IHC score to classify the degree of PTK7 expression and evaluate clinicopathological factors and prognosis. Results The number of the high expression group (IHC Score 2 or 3) was 45 cases and that of the low expression group (IHC Score 0 or 1) was 35 cases. A significant difference between high expression and low expression groups was found in the N category (p = .008), degree of differentiation (p 
ISSN:2057-4347
2057-4347
DOI:10.1002/cre2.553