Liver fibrosis assessment: MR and US elastography

Elastography has emerged as a preferred non-invasive imaging technique for the clinical assessment of liver fibrosis. Elastography methods provide liver stiffness measurement (LSM) as a surrogate quantitative biomarker for fibrosis burden in chronic liver disease (CLD). Elastography can be performed...

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Bibliographic Details
Published in:Abdominal imaging 2022-09, Vol.47 (9), p.3037-3050
Main Authors: Ozturk, Arinc, Olson, Michael C., Samir, Anthony E., Venkatesh, Sudhakar K.
Format: Article
Language:English
Subjects:
Biomarkers
Cirrhosis
Elasticity Imaging Techniques - methods
Fibrosis
Gastroenterology
Hepatology
Humans
Imaging
Imaging techniques
Liver
Liver - diagnostic imaging
Liver - pathology
Liver cirrhosis
Liver Cirrhosis - diagnostic imaging
Liver Cirrhosis - pathology
Liver diseases
Magnetic Resonance Imaging - methods
Mechanical properties
Medicine
Medicine & Public Health
Modulus of elasticity
Non-alcoholic Fatty Liver Disease - pathology
Radiology
Scars
Shear modulus
Special Section: Quantitative Imaging
Steatosis
Stiffness
Therapeutic applications
Ultrasonic imaging
Ultrasonic methods
Ultrasonic testing
Ultrasound
Vibration
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Summary:Elastography has emerged as a preferred non-invasive imaging technique for the clinical assessment of liver fibrosis. Elastography methods provide liver stiffness measurement (LSM) as a surrogate quantitative biomarker for fibrosis burden in chronic liver disease (CLD). Elastography can be performed either with ultrasound or MRI. Currently available ultrasound-based methods include strain elastography, two-dimensional shear wave elastography (2D-SWE), point shear wave elastography (pSWE), and vibration-controlled transient elastography (VCTE). MR Elastography (MRE) is widely available as two-dimensional gradient echo MRE (2D-GRE-MRE) technique. US-based methods provide estimated Young’s modulus (eYM) and MRE provides magnitude of the complex shear modulus. MRE and ultrasound methods have proven to be accurate methods for detection of advanced liver fibrosis and cirrhosis. Other clinical applications of elastography include liver decompensation prediction, and differentiation of non-alcoholic steatohepatitis (NASH) from simple steatosis (SS). In this review, we briefly describe the different elastography methods, discuss current clinical applications, and provide an overview of advances in the field of liver elastography.
ISSN:2366-004X
2366-0058
DOI:10.1007/s00261-021-03269-4