The clinical evolution of lichen planus pemphigoides

Lichen planus pemphigoides (LPP) is a rare autoimmune subepidermal blistering disease characterized by lichenoid and bullous lesions. LPP is generally thought to be idiopathic, possibly related to medication or malignancy, or potentially the result of long-standing lichenoid inflammation damaging th...

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Bibliographic Details
Published in:Proceedings - Baylor University. Medical Center 2022, Vol.35 (3), p.352-353
Main Authors: Alkul, Mahmud, Truitt, Jay, Tarbox, Michelle B
Format: Article
Language:English
Subjects:
Autoimmune diseases
Case Report
Case Studies
Skin diseases
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Summary:Lichen planus pemphigoides (LPP) is a rare autoimmune subepidermal blistering disease characterized by lichenoid and bullous lesions. LPP is generally thought to be idiopathic, possibly related to medication or malignancy, or potentially the result of long-standing lichenoid inflammation damaging the basement membrane zone leading to epitope spreading. The histological appearance of lichenoid and bullous lesions in LPP resembles findings of lichen planus and bullous pemphigoid, respectively. We present a case of LPP in a 64-year-old woman with a brief historical review of the establishment of LPP as a separate disease entity and a discussion of similarities and differences of LPP with other lichenoid and blistering dermatoses.
ISSN:0899-8280
1525-3252
DOI:10.1080/08998280.2021.2022065