Two Lambert-Eaton Myasthenic Syndrome Patients with Ameliorated Activities of Daily Living Due to Cholinesterase Inhibitors

We herein report two P/Q-type voltage-gated calcium channel (VGCC) antibody-positive Lambert-Eaton myasthenic syndrome (LEMS) patients who responded dramatically to cholinesterase inhibitors. Patient 1, a 76-year-old man, had small-cell lung cancer and developed LEMS during chemotherapy. When sympto...

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Bibliographic Details
Published in:Internal Medicine 2022/04/01, Vol.61(7), pp.1063-1065
Main Authors: Yamasaki, Hiroshi, Futamura, Naonobu, Funakawa, Itaru, Kohara, Nobuo, Yoshimura, Shunsuke, Motomura, Masakatsu
Format: Article
Language:English
Subjects:
3,4-diaminopyridine
Activities of Daily Living
Aged
Calcium channels (P/Q-type)
Calcium channels (Q-type)
Calcium channels (voltage-gated)
Case Report
Chemotherapy
Cholinesterase inhibitors
Cholinesterase Inhibitors - therapeutic use
electrophysiological examination
Gait
Humans
Internal medicine
Lambert-Eaton myasthenic syndrome
Lambert-Eaton myasthenic syndrome (LEMS)
Lambert-Eaton Myasthenic Syndrome - diagnosis
Lung Neoplasms - drug therapy
Male
Movement disorders
Neuromuscular junctions
Patients
Pyridostigmine
Small cell lung carcinoma
Small Cell Lung Carcinoma - complications
Small Cell Lung Carcinoma - drug therapy
treatment algorithm
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Description
Summary:We herein report two P/Q-type voltage-gated calcium channel (VGCC) antibody-positive Lambert-Eaton myasthenic syndrome (LEMS) patients who responded dramatically to cholinesterase inhibitors. Patient 1, a 76-year-old man, had small-cell lung cancer and developed LEMS during chemotherapy. When symptomatic treatment was started with pyridostigmine, gait disturbance was ameliorated, and his modified Rankin scale decreased from 4 points to 3 points. Patient 2, a 68-year-old man, had cancer-free LEMS. Distigmine bromide was very effective and ameliorated not only his gait disturbance but also autonomic symptoms, and his modified Rankin scale decreased from 2 points to 1 point. Cholinesterase inhibitors alone may be effective in a small portion of LEMS patients.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.7902-21