Trinorlabdane diterpenoid alkaloids featuring an unprecedented skeleton with anti-inflammatory and anti-viral activities from Forsythia suspensa

Two unique trinorlabdane diterpenoid alkaloids, forsyqinlingines A (1) and B (2), were isolated from the ripe fruits of . Their structures, including absolute stereochemical configurations, were fully elucidated from extensive spectroscopy experiments, single-crystal X-ray diffraction, and electroni...

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Bibliographic Details
Published in:RSC advances 2021-09, Vol.11 (47), p.29684-29689
Main Authors: Li, Wei, Zhao, Lin, Sun, Li-Tong, Xie, Ze-Ping, Zhang, Shu-Min, Yue, Xi-Dian, Dai, Sheng-Jun
Format: Article
Language:English
Subjects:
Alkaloids
Chemistry
Crystals
Dichroism
Leukocytes
Single crystals
Viruses
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Summary:Two unique trinorlabdane diterpenoid alkaloids, forsyqinlingines A (1) and B (2), were isolated from the ripe fruits of . Their structures, including absolute stereochemical configurations, were fully elucidated from extensive spectroscopy experiments, single-crystal X-ray diffraction, and electronic circular dichroism (ECD). In addition, a plausible biosynthetic pathway for the formation of compounds 1 and 2 in was also proposed. , the two C -labdane diterpenoid alkaloids exhibited anti-inflammatory activities by inhibiting the release of β-glucuronidase in rat polymorphonuclear leukocytes (PMNs), and antiviral activities against influenza A (H1N1) virus and respiratory syncytial virus (RSV).
ISSN:2046-2069
2046-2069
DOI:10.1039/d1ra05760j