Sample preparation considerations for surface and crystalline properties and ecotoxicity of bare and silica-coated magnetite nanoparticles

Magnetite (Fe 3 O 4 ) nanoparticles (NPs) have widely used in various fields, including in medicine, due to their (super)paramagnetic properties. This requires a thorough evaluation of their possible hazardous effects. However, there is no standard procedure for the preparation of oxidation-prone NP...

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Bibliographic Details
Published in:RSC advances 2021-09, Vol.11 (51), p.32227-32235
Main Authors: Bondarenko, Lyubov, Terekhova, Vera, Kahru, Anne, Dzhardimalieva, Gulzhian, Kelbysheva, Elena, Tropskaya, Natalya, Kydralieva, Kamila
Format: Article
Language:English
Subjects:
Chemistry
Iron oxides
Magnetic properties
Magnetite
Nanoparticles
Oxidation
Photon correlation spectroscopy
Silicon dioxide
Surface charge
Toxicity
Ultrasonic testing
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Summary:Magnetite (Fe 3 O 4 ) nanoparticles (NPs) have widely used in various fields, including in medicine, due to their (super)paramagnetic properties. This requires a thorough evaluation of their possible hazardous effects. However, there is no standard procedure for the preparation of oxidation-prone NPs (such as magnetite) before subjecting them to biological assays. In this study we used Fe 3 O 4 NPs (bare and silica-coated) as test samples to compare different preparation methods (ultrasound, centrifugation and filteration of NPs suspensions) based on X-ray and dynamic light scattering analysis and evaluation of microstructure and surface charge. After oxidation and functionalization, all samples retained their superparamagnetic behaviour. The toxicity of NP suspensions obtained by the methods described for Paramecium caudatum ciliates and Sinapis alba plants was evaluated. The charge and surface reactivity of magnetite nanoparticles can be affected by the different separation methods leading to their toxicity changes.
ISSN:2046-2069
2046-2069
DOI:10.1039/d1ra05703k