Co-precipitation polymerization of dual functional monomers and polystyrene- co -divinylbenzene for ciprofloxacin imprinted polymer preparation

Novel ciprofloxacin composite imprinted materials are synthesized by using co-precipitation polymerization of dual functional monomers (methacrylic acid and 2-vinylpyridine) and polystyrene- -divinylbenzene. The intermolecular interactions between monomers and template are evaluated by molecular mod...

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Bibliographic Details
Published in:RSC advances 2021-10, Vol.11 (54), p.34281-34290
Main Authors: Nguyen, Huy Truong, Vuong Bui, Nhat Thao, Kanhounnon, Wilfried G, Vu Huynh, Kim Long, Nguyen, Tran-Van-Anh, Nguyen, Hien Minh, Do, Minh Huy, Badawi, Michael, Thach, Ut Dong
Format: Article
Language:English
Subjects:
Adsorption
Cartridges
Chemical Sciences
Chemistry
Coprecipitation
Divinylbenzene
Hydrogen bonding
Imprinted polymers
Methacrylic acid
Monomers
Polymerization
Polymers
Polystyrene resins
Solid phases
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Summary:Novel ciprofloxacin composite imprinted materials are synthesized by using co-precipitation polymerization of dual functional monomers (methacrylic acid and 2-vinylpyridine) and polystyrene- -divinylbenzene. The intermolecular interactions between monomers and template are evaluated by molecular modeling analysis. The physicochemical properties of the obtained polymers are characterized using FT-IR, TGA, and SEM. Batch adsorption experiments are used to investigate adsorption properties (kinetic, pH, and isotherm). These polymers are employed to prepare the solid phase extraction cartridges, and their extraction performances are analyzed by the HPLC-UV method. DFT calculations indicate that hydrogen bonding and π-π stacking are the driving forces for the formation of selective rebinding sites. The obtained polymers exhibit excellent adsorption properties, including fast kinetics and high adsorption capacity (up to 10.28 mg g ) with an imprinted factor of 2.55. The Scatchard analysis indicates the presence of specific high-affinity adsorption sites on the imprinted polymer. These absorbents are employed to extract CIP in river water with recoveries in the range of 65.97-119.26% and the relative standard deviation of 3.59-14.01%. Furthermore, the used cartridges could be reused at least eight times without decreasing their initial adsorption capacity.
ISSN:2046-2069
2046-2069
DOI:10.1039/d1ra05505d